A potential role for cyclophosphamide in the mitigation of acute respiratory distress syndrome among patients with SARS-CoV-2

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorRevannasiddaiah, Swaroop-
Autor(es): dc.creatorKumar Devadas, Santhosh-
Autor(es): dc.creatorPalassery, Rasmi-
Autor(es): dc.creatorKumar Pant, Nirdosh-
Autor(es): dc.creatorMaka, Vinayak V.-
Data de aceite: dc.date.accessioned2026-02-09T12:20:40Z-
Data de disponibilização: dc.date.available2026-02-09T12:20:40Z-
Data de envio: dc.date.issued2020-06-22-
Data de envio: dc.date.issued2020-06-22-
Data de envio: dc.date.issued2020-10-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/41522-
Fonte completa do material: dc.identifierhttps://www.sciencedirect.com/science/article/pii/S030698772031063X-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1159396-
Descrição: dc.descriptionWhile humanity struggles to develop a vaccine against SARS-CoV-2, it is imperative that effective and affordable therapeutic strategies be evolved. Since a majority of the SARS-CoV-2 deaths are due to acute respiratory distress syndrome (ARDS), a strategy to mitigate the same could save countless lives. Since SARS-CoV-2 related ARDS has a strong immunological component, many investigators are utilizing monoclonal antibodies against IL-6, TNF-alpha and CCR5. However, targeting a single cytokine with an expensive monoclonal antibody could be a less pragmatic approach. We propose the use of cyclophosphamide as an immunomodulator, given its proven role in various settings including autoimmune diseases, and in the post-haploidentical stem cell transplant. Cyclophosphamide could deplete cytotoxic and effector T cell populations while relatively sparing the regulatory T cells (Tregs). Cyclophosphamide could tip the balance away from the overtly pro-inflammatory and could be a less expensive and effective alternative to the currently investigated monoclonal antibodies.-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceMedical Hypotheses-
Palavras-chave: dc.subjectCyclophosphamide-
Palavras-chave: dc.subjectRegulatory T cells-
Palavras-chave: dc.subjectTreg-
Palavras-chave: dc.subjectAcute Respiratory Distress Syndrome (ARDS)-
Palavras-chave: dc.subjectSevere Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-
Palavras-chave: dc.subjectCOVID-19-
Título: dc.titleA potential role for cyclophosphamide in the mitigation of acute respiratory distress syndrome among patients with SARS-CoV-2-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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