Estimation of Renin-Angiotensin-Aldosterone-System (RAAS)-Inhibitor effect on COVID-19 outcome: a meta-analysis

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Autor(es): dc.creatorPirola, Carlos J.-
Autor(es): dc.creatorSookoian, Silvia-
Data de aceite: dc.date.accessioned2026-02-09T12:17:20Z-
Data de disponibilização: dc.date.available2026-02-09T12:17:20Z-
Data de envio: dc.date.issued2020-08-04-
Data de envio: dc.date.issued2020-08-04-
Data de envio: dc.date.issued2020-08-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/42196-
Fonte completa do material: dc.identifierhttps://www.sciencedirect.com/science/article/pii/S0163445320303297-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1158292-
Descrição: dc.descriptionBackground and rationale Some studies of hospitalized patients suggested that the risk of death and/or severe illness due to COVID-19 is not associated with the use of angiotensin-converting enzyme inhibitors (ACEIs) and/or angiotensin II receptor type 1 blockers (ARBs). Nevertheless, some controversy still exists and there is limited information of the ACEIs/ARBs effect size on COVID-19 prognosis. Aim and Methods We aimed to measure the effect of ACEIs and/or ARBs on COVID-19 severe clinical illness by a meta-analysis. Literature search included all studies published since the COVID-19 outbreak began (December 2019) until May 9, 2020. We analyzed information from studies that included tested COVID-19 patients with arterial hypertension as comorbidity prior to hospital admission and history of taking ACEIs, ARBs, or ACEIs/ARBs. Results We included 16 studies that involved 24,676 COVID-19 patients, and we compared patients with critical (n = 4134) vs. non-critical (n = 20,542) outcomes. The overall assessment by estimating random effects shows that the use of ACEIs/ARBs is not associated with higher risk of in-hospital-death and/or severe illness among hypertensive patients with COVID-19 infection. On the contrary, effect estimate shows an overall protective effect of RAAS inhibitors/blockers (ACEIs, ARBs, and/or ACEIs/ARBs) with ∼ 23 % reduced risk of death and/or critical disease (OR: 0.768, 95%CI: 0.651-0.907, p=0.0018). The use of ACEIs (OR:0.652, 95%CI:0.478-0.891, p=0.0072) but not ACEIs/ARBs (OR:0.867, 95%CI:0.638-1.179, p =NS) or ARBs alone (OR:0.810, 95%CI:0.629-1.044, p=NS) may explain the overall protection displayed by RAAS intervention combined. Conclusion RAAS inhibitors might be associated with better COVID-19 prognosis.-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceJournal of Infection-
Palavras-chave: dc.subjectCOVID-19-
Palavras-chave: dc.subjectHypertension-
Palavras-chave: dc.subjectDiabetes-
Palavras-chave: dc.subjectCardiovascular disease-
Palavras-chave: dc.subjectPrognosis-
Palavras-chave: dc.subjectRenin-Angiotensin-Aldosterone-System (RAAS) inhibitors-
Palavras-chave: dc.subjectAngiotensin II-converting enzyme inhibitors-
Palavras-chave: dc.subjectAngiotensin II receptor type 1 blockers-
Título: dc.titleEstimation of Renin-Angiotensin-Aldosterone-System (RAAS)-Inhibitor effect on COVID-19 outcome: a meta-analysis-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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