COVID-19 cytokine storm: the anger of inflammation

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorMahmudpour, Mehdi-
Autor(es): dc.creatorRoozbeh, Jamshid-
Autor(es): dc.creatorKeshavarz, Mohsen-
Autor(es): dc.creatorFarrokhi, Shokrollah-
Autor(es): dc.creatorNabipour, Iraj-
Data de aceite: dc.date.accessioned2026-02-09T12:14:34Z-
Data de disponibilização: dc.date.available2026-02-09T12:14:34Z-
Data de envio: dc.date.issued2020-12-01-
Data de envio: dc.date.issued2020-12-01-
Data de envio: dc.date.issued2020-09-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/45719-
Fonte completa do material: dc.identifierhttps://www.sciencedirect.com/science/article/abs/pii/S1043466620301678-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1157358-
Descrição: dc.descriptionPatients with COVID-19 who require ICU admission might have the cytokine storm. It is a state of out-of-control release of a variety of inflammatory cytokines. The molecular mechanism of the cytokine storm has not been explored extensively yet. The attachment of SARS-CoV-2 spike glycoprotein with angiotensin-converting enzyme 2 (ACE2), as its cellular receptor, triggers complex molecular events that leads to hyperinflammation. Four molecular axes that may be involved in SARS-CoV-2 driven inflammatory cytokine overproduction are addressed in this work. The virus-mediated down-regulation of ACE2 causes a burst of inflammatory cytokine release through dysregulation of the renin-angiotensin-aldosterone system (ACE/angiotensin II/AT1R axis), attenuation of Mas receptor (ACE2/MasR axis), increased activation of [des-Arg9]-bradykinin (ACE2/bradykinin B1R/DABK axis), and activation of the complement system including C5a and C5b-9 components. The molecular clarification of these axes will elucidate an array of therapeutic strategies to confront the cytokine storm in order to prevent and treat COVID-19 associated acute respiratory distress syndrome.-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceCytokine-
Palavras-chave: dc.subjectCOVID-19-
Palavras-chave: dc.subjectSevere Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-
Palavras-chave: dc.subjectAngiotensin-converting enzyme 2 (ACE2)-
Palavras-chave: dc.subjectCytokine storm-
Título: dc.titleCOVID-19 cytokine storm: the anger of inflammation-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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