Evaluation of hypoxia inducible factor targeting pharmacological drugs as antileishmanial agents

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorDal'Bó-Pelegrini, Marina-
Autor(es): dc.creatorPereira, Juliana Biar-
Autor(es): dc.creatorCosta, Solange dos Santos-
Autor(es): dc.creatorSalazar-Terreros, Myriam Janeth-
Autor(es): dc.creatorDegrossoli, Adriana-
Autor(es): dc.creatorGiorgio, Selma-
Data de aceite: dc.date.accessioned2026-02-09T12:13:40Z-
Data de disponibilização: dc.date.available2026-02-09T12:13:40Z-
Data de envio: dc.date.issued2018-05-24-
Data de envio: dc.date.issued2018-05-24-
Data de envio: dc.date.issued2016-07-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/29312-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1157034-
Descrição: dc.descriptionObjective: To evaluate whether hypoxia inducible factor (HIF-1α) targeting pharmacological drugs, echinomycin, resveratrol and CdCl2 which inhibit HIF-1α stimulation, and mimosine, which enhances the stability of HIF-1α present antileishmanial properties. Methods: The leishmanicidal effect of drugs was evaluated in mouse macrophages and Balb/c mouse model for cutaneous leishmaniosis. Results: Resveratrol and CdCl2 reduced the parasite load [IC50, (27.3 ± 2.25) μM and (24.8 ± 0.95) μM, respectively]. The IC50 value of echinomycin was (22.7 ± 7.36) nM and mimosine did not alter the parasite load in primary macrophages. The macrophage viability IC50 values for resveratrol, echinomycin and CdCl2 and mimosine were >40 μM, >100 nM, >200 μM and>2 000 μM, respectively. In vivo no differences between cutaneous lesions from control, resveratrol- and echinomycin-treated Balb/c mice were detected. Conclusions: Resveratrol, echinomycin and CdCl2 reduce parasite survival in vitro. The HIF-1α targeting pharmacological drugs require further study to more fully determine their anti-Leishmania potential and their role in therapeutic strategies.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Publicador: dc.publisherHainan Medical College-
Direitos: dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International-
Direitos: dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International-
Direitos: dc.rightsacesso aberto-
Direitos: dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0/-
Direitos: dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0/-
???dc.source???: dc.sourceAsian Pacific Journal of Tropical Medicine-
Palavras-chave: dc.subjectLeishmaniosis-
Palavras-chave: dc.subjectHypoxia inducible factor-
Palavras-chave: dc.subjectResveratrol-
Palavras-chave: dc.subjectEchinomycin-
Palavras-chave: dc.subjectCadmium chloride (CdCl2)-
Palavras-chave: dc.subjectMimosine-
Título: dc.titleEvaluation of hypoxia inducible factor targeting pharmacological drugs as antileishmanial agents-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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