Voluntary physical activity mitigates alveolar bone loss in mice with ligature-induced experimental periodontitis

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorBertolini, Natalia O.-
Autor(es): dc.creatorPereira, Gustavo J. S.-
Autor(es): dc.creatorSilva, Viviam O.-
Autor(es): dc.creatorMolon, Rafael Scaf de-
Autor(es): dc.creatorMorari, Joseane-
Autor(es): dc.creatorVelloso, Lício A.-
Autor(es): dc.creatorAndrade, Eric F.-
Autor(es): dc.creatorPereira, Luciano J.-
Autor(es): dc.creatorMoura, Rodrigo F.-
Data de aceite: dc.date.accessioned2026-02-09T12:13:09Z-
Data de disponibilização: dc.date.available2026-02-09T12:13:09Z-
Data de envio: dc.date.issued2022-08-05-
Data de envio: dc.date.issued2022-08-05-
Data de envio: dc.date.issued2022-08-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/50867-
Fonte completa do material: dc.identifierhttps://doi.org/10.1016/j.archoralbio.2022.105451-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1156849-
Descrição: dc.descriptionObjective: To investigate the effect of voluntary physical activity (VPA) on inflammatory profile and the progression of experimental periodontal disease (PD) in mice. Methods: Male C57BL/6 mice were randomly distributed into Control; VPA; PD and PD/VPA groups. We registered VPA (total volume of revolutions) and average speed (revolutions/minute) in a free running wheel for 30 days. On the 15th day, animals from the PD and PD/VPA groups received ligatures on the upper second molars bilaterally. On the 30th day animals were euthanized, and PD progression was assessed by measuring alveolar bone loss (ABL - the linear distance between the cemento-enamel junction and the alveolar bone crest on the teeth buccal surface). Gene expression of RANKL (kappa nuclear factor B receptor) OPG (osteoprotegerin), IL-1β (interleukin 1 beta), IL-6 (interleukin 6) and TNF-α (tumor necrosis factor alpha) were evaluated by real-time PCR (quantitative Polymerase Chain Reaction - relative gene expression). Results: The total volume of physical activity and the activity speed decreased along the seven days after ligatureplacement (p < 0.05), returning to a similar pattern in relation to VPA group. Ligature placement produced significant bone resorption, and increased RANKL, IL-1β, IL-6 and TNF-α expression. VPA reduced ABL (p < 0,05) and the expression of TNF-α and IL-1β, whereas increased OPG expression. Conclusion: Animals induced to PD with access to the VPA wheel presented both lower gingival inflammation and less alveolar bone resorption in comparison to animals without access to the wheel.-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceArchives of Oral Biology-
Palavras-chave: dc.subjectInflammation-
Palavras-chave: dc.subjectVoluntary physical activity-
Palavras-chave: dc.subjectVoluntary exercise-
Palavras-chave: dc.subjectPeriodontitis-
Palavras-chave: dc.subjectFree running wheel-
Palavras-chave: dc.subjectLocomotor behavior-
Palavras-chave: dc.subjectPeriodontite-
Palavras-chave: dc.subjectAtividade física voluntária-
Palavras-chave: dc.subjectComportamento locomotor-
Título: dc.titleVoluntary physical activity mitigates alveolar bone loss in mice with ligature-induced experimental periodontitis-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

Não existem arquivos associados a este item.