Tumor growth reduction is regulated at the gene level in walker 256 tumor-bearing rats supplemented with fish oil rich in EPA and DHA

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Autor(es): dc.creatorBorghetti, G.-
Autor(es): dc.creatorYamazaki, R. K.-
Autor(es): dc.creatorCoelho, I.-
Autor(es): dc.creatorPequito, D. C. T.-
Autor(es): dc.creatorSchiessel, D. L.-
Autor(es): dc.creatorKryczyk, M.-
Autor(es): dc.creatorMamus, R.-
Autor(es): dc.creatorNaliwaiko, K.-
Autor(es): dc.creatorFernandes, L. C.-
Data de aceite: dc.date.accessioned2026-02-09T12:13:06Z-
Data de disponibilização: dc.date.available2026-02-09T12:13:06Z-
Data de envio: dc.date.issued2019-11-12-
Data de envio: dc.date.issued2019-11-12-
Data de envio: dc.date.issued2013-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/37621-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1156831-
Descrição: dc.descriptionWe investigated the effect of fish oil (FO) supplementation on tumor growth, cyclooxygenase 2 (COX-2), peroxisome proliferator-activated receptor gamma (PPARc), and RelA gene and protein expression in Walker 256 tumor-bearing rats. Male Wistar rats (70 days old) were fed with regular chow (group W) or chow supplemented with 1 g/kg body weight FO daily (group WFO) until they reached 100 days of age. Both groups were then inoculated with a suspension of Walker 256 ascitic tumor cells (36107 cells/mL). After 14 days the rats were killed, total RNA was isolated from the tumor tissue, and relative mRNA expression was measured using the 2-DDCT method. FO significantly decreased tumor growth (W=13.18±1.58 vs WFO=5.40±0.88 g, P,0.05). FO supplementation also resulted in a significant decrease in COX-2 (W=100.1±1.62 vs WFO=59.39±5.53, P,0.001) and PPARc (W=100.4±1.04 vs WFO=88.22±1.46, P,0.05) protein expression. Relative mRNA expression was W=1.06±0.022 vs WFO=0.31±0.04 (P,0.001) for COX-2, W=1.08±0.02 vs WFO=0.52±0.08 (P,0.001) for PPARc, and W=1.04±0.02 vs WFO=0.82±0.04 (P,0.05) for RelA. FO reduced tumor growth by attenuating inflammatory gene expression associated with carcinogenesis.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Publicador: dc.publisherAssociação Brasileira de Divulgação Científica-
Direitos: dc.rightsAttribution 4.0 International-
Direitos: dc.rightsAttribution 4.0 International-
Direitos: dc.rightsacesso aberto-
Direitos: dc.rightshttp://creativecommons.org/licenses/by/4.0/-
Direitos: dc.rightshttp://creativecommons.org/licenses/by/4.0/-
???dc.source???: dc.sourceBrazilian Journal of Medical and Biological Research-
Palavras-chave: dc.subjectCancer-
Palavras-chave: dc.subjectFish oil-
Palavras-chave: dc.subjectGene expression-
Título: dc.titleTumor growth reduction is regulated at the gene level in walker 256 tumor-bearing rats supplemented with fish oil rich in EPA and DHA-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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