Structural features of coronavirus SARS-CoV-2 spike protein: targets for vaccination

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorSternberg, Ariane-
Autor(es): dc.creatorNaujokat, Cord-
Data de aceite: dc.date.accessioned2026-02-09T12:12:41Z-
Data de disponibilização: dc.date.available2026-02-09T12:12:41Z-
Data de envio: dc.date.issued2020-08-03-
Data de envio: dc.date.issued2020-08-03-
Data de envio: dc.date.issued2020-09-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/42182-
Fonte completa do material: dc.identifierhttps://www.sciencedirect.com/science/article/pii/S0024320520308079-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1156682-
Descrição: dc.descriptionVarious human pathogenic viruses employ envelope glycoproteins for host cell receptor recognition and binding, membrane fusion and viral entry. The spike (S) glycoprotein of betacoronavirus SARS-CoV-2 is a homotrimeric class I fusion protein that exists in a metastable conformation for cleavage by host cell proteases furin and TMPRSS2, thereby undergoing substantial structural rearrangement for ACE2 host cell receptor binding and subsequent viral entry by membrane fusion. The S protein is densely decorated with N-linked glycans protruding from the trimer surface that affect S protein folding, processing by host cell proteases and the elicitation of humoral immune response. Deep insight into the sophisticated structure of SARS-CoV-2 S protein may provide a blueprint for vaccination strategies, as reviewed herein.-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceLife Sciences-
Palavras-chave: dc.subjectCoronavirus-
Palavras-chave: dc.subjectSevere Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-
Palavras-chave: dc.subjectSpike protein-
Palavras-chave: dc.subjectProtein structure-
Palavras-chave: dc.subjectReceptor binding domain-
Palavras-chave: dc.subjectViral fusion protein-
Palavras-chave: dc.subjectAngiotensin-converting enzyme 2 (ACE2)-
Palavras-chave: dc.subjectVaccination-
Palavras-chave: dc.subjectImmune response-
Título: dc.titleStructural features of coronavirus SARS-CoV-2 spike protein: targets for vaccination-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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