Protective effect of β-D-glucan and glutamine on the genomic instability induced by Cytarabine/Ara-C in BALB/c mice

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorSilva, Priscilla Mirian de Souza-
Autor(es): dc.creatorSousa, Raimundo Vicente de-
Autor(es): dc.creatorSimão, Anderson Assaid-
Autor(es): dc.creatorCesar, Pedro Henrique Souza-
Autor(es): dc.creatorTrento, Marcus Vinicius Cardoso-
Autor(es): dc.creatorMarcussi, Silvana-
Data de aceite: dc.date.accessioned2026-02-09T12:12:39Z-
Data de disponibilização: dc.date.available2026-02-09T12:12:39Z-
Data de envio: dc.date.issued2019-06-13-
Data de envio: dc.date.issued2019-06-13-
Data de envio: dc.date.issued2018-10-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/34758-
Fonte completa do material: dc.identifierhttps://www.sciencedirect.com/science/article/pii/S0141813017339673-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1156672-
Descrição: dc.descriptionProphylactic antibiotics and growth promoters have been substituted, mainly for livestock, by immunomodulators and intestinal health promoters - such as β-D-glucans and glutamine. The aim of this study was to verify the beneficial effects of β-D-glucans and glutamine against Cytarabine/Ara-C, evaluating the DNA damage in leukocytes, the leukogram, and the mitotic index of intestinal crypts cells. Balb/C mice received treatment with β-D-glucan (80 mg/Kg), glutamine (150 mg/Kg), or both, for 21 days. On the last two days of this period, Ara-C was administered (1.8 mg/animal) by intraperitoneal injection every 12 h. The animals submitted to the treatment with Ara-C presented the highest genotoxic index, a significant leukopenia, and a decrease in the mitotic index of the intestinal crypts cells. Treatment with β-D-glucan protected the leukocytes against DNA fragmentation induced by Ara-C. Glutamine alone promoted maintenance of the mitotic index and, in association with β-Dglucan, reduced leukopenia. Thus, the use of β-D-glucan and glutamine proved to be beneficial to intestinal tropism. This can happen once the damage to the genetic material, prevented by the treatments with β-D-glucan and glutamine, can result in genotoxicity. Not only this, but it might be capable of turning into a mutagenesis, with consequential physiopathological alterations.-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceInternational Journal of Biological Macromolecules-
Palavras-chave: dc.subjectAntigenotoxic potential-
Palavras-chave: dc.subjectMitotic index-
Palavras-chave: dc.subjectComet assay-
Palavras-chave: dc.subjectβ-D-glucan supplementation-
Palavras-chave: dc.subjectGlutamine supplementation-
Palavras-chave: dc.subjectFunctional carbohydrates-
Título: dc.titleProtective effect of β-D-glucan and glutamine on the genomic instability induced by Cytarabine/Ara-C in BALB/c mice-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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