Hyper and hypometabolism are not related to nutritional status of patients on the waiting list for liver transplantation

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Autor(es): dc.creatorFerreira, Lívia Garcia-
Autor(es): dc.creatorSantos, Laís Ferreira-
Autor(es): dc.creatorSilva, Thayná Ribeiro Neri da-
Autor(es): dc.creatorAnastácio, Lucilene Rezende-
Autor(es): dc.creatorLima, Agnaldo Soares-
Autor(es): dc.creatorCorreia, Maria Isabel Toulson Davisson-
Data de aceite: dc.date.accessioned2026-02-09T12:10:53Z-
Data de disponibilização: dc.date.available2026-02-09T12:10:53Z-
Data de envio: dc.date.issued2020-01-29-
Data de envio: dc.date.issued2020-01-29-
Data de envio: dc.date.issued2014-10-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/38775-
Fonte completa do material: dc.identifierhttps://www.sciencedirect.com/science/article/pii/S0261561413002756-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1156062-
Descrição: dc.descriptionBackground & aims Metabolic disorders and malnutrition are well known conditions reported in patients with liver disease (LD), but the relationship between them are underexplored. So, the aim of this study was to assess the resting energy expenditure (REE) of these patients, identifying the prevalence of hyper- and hypometabolism. In addition, to evaluate whether malnutrition and clinical variables were associated with REE and metabolic disorders. Methods The REE was measured by indirect calorimetry and predicted by the Harris and Benedict formula (REEHB). Nutritional status was assessed by different methods. The etiology, severity and complications of LD were also evaluated. Results A total of 81 patients were assessed. The measured REE was 1587.5 ± 426.6 kcal. The REE was overestimated by the REEHB (REE:REEHB <0.8) in 7.4% and underestimated (REE:REEHB >1.2) in 24.7% of the patients. The REE was lower in malnourished patients (p < 0.05). However, hyper- and hypometabolism were not associated with nutritional status (p > 0.05). The REE and hypermetabolism were not associated with LD, but hypometabolic patients had a higher prevalence of Child C, and had higher values for MELD, INR and total bilirubin (p < 0.05). After multiple regression analyses, the REE was significantly associated (p < 0.05) with intracellular body water, arm muscle area and serum glucose. Serum glucose was only significantly associated (p < 0.05) with hypermetabolism, and INR with hypometabolism. Conclusion Changes in resting metabolism are present but not universal. The hypermetabolism was associated with extrahepatic factors, and hypometabolism with the severity of LD. Under these conditions in the clinical setting, calculated energy requirements using the HB formula should be adjusted.-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceClinical Nutrition-
Palavras-chave: dc.subjectEnergy metabolism-
Palavras-chave: dc.subjectMalnutrition-
Palavras-chave: dc.subjectLiver transplantation-
Título: dc.titleHyper and hypometabolism are not related to nutritional status of patients on the waiting list for liver transplantation-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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