Quantifying the arousal threshold using polysomnography in obstructive sleep apnea

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorSands, Scott A.-
Autor(es): dc.creatorTerrill, Philip I.-
Autor(es): dc.creatorEdwards, Bradley A.-
Autor(es): dc.creatorMontemurro, Luigi Taranto-
Autor(es): dc.creatorAzarbarzin, Ali-
Autor(es): dc.creatorMarques, Melania-
Autor(es): dc.creatorMelo, Camila M. de-
Autor(es): dc.creatorLoring, Stephen H.-
Autor(es): dc.creatorButler, James P.-
Autor(es): dc.creatorWhite, David P.-
Autor(es): dc.creatorWellman, Andrew-
Data de aceite: dc.date.accessioned2026-02-09T12:10:34Z-
Data de disponibilização: dc.date.available2026-02-09T12:10:34Z-
Data de envio: dc.date.issued2019-02-25-
Data de envio: dc.date.issued2019-02-25-
Data de envio: dc.date.issued2018-01-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/33017-
Fonte completa do material: dc.identifierhttps://academic.oup.com/sleep/article/41/1/zsx183/4608578-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1155943-
Descrição: dc.descriptionStudy Objectives Precision medicine for obstructive sleep apnea (OSA) requires noninvasive estimates of each patient’s pathophysiological “traits.” Here, we provide the first automated technique to quantify the respiratory arousal threshold—defined as the level of ventilatory drive triggering arousal from sleep—using diagnostic polysomnographic signals in patients with OSA. Methods Ventilatory drive preceding clinically scored arousals was estimated from polysomnographic studies by fitting a respiratory control model (Terrill et al.) to the pattern of ventilation during spontaneous respiratory events. Conceptually, the magnitude of the airflow signal immediately after arousal onset reveals information on the underlying ventilatory drive that triggered the arousal. Polysomnographic arousal threshold measures were compared with gold standard values taken from esophageal pressure and intraoesophageal diaphragm electromyography recorded simultaneously (N = 29). Comparisons were also made to arousal threshold measures using continuous positive airway pressure (CPAP) dial-downs (N = 28). The validity of using (linearized) nasal pressure rather than pneumotachograph ventilation was also assessed (N = 11). Results Polysomnographic arousal threshold values were correlated with those measured using esophageal pressure and diaphragm EMG (R = 0.79, p < .0001; R = 0.73, p = .0001), as well as CPAP manipulation (R = 0.73, p < .0001). Arousal threshold estimates were similar using nasal pressure and pneumotachograph ventilation (R = 0.96, p < .0001). Conclusions The arousal threshold in patients with OSA can be estimated using polysomnographic signals and may enable more personalized therapeutic interventions for patients with a low arousal threshold.-
Idioma: dc.languageen-
Publicador: dc.publisherOxford Academic-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceSleep-
Palavras-chave: dc.subjectArousability-
Palavras-chave: dc.subjectPathophysiology-
Palavras-chave: dc.subjectPersonalized medicine-
Palavras-chave: dc.subjectObstructive sleep apnea-
Palavras-chave: dc.subjectFisiopatologia-
Palavras-chave: dc.subjectMedicina personalizada-
Palavras-chave: dc.subjectApneia obstrutiva do sono-
Título: dc.titleQuantifying the arousal threshold using polysomnography in obstructive sleep apnea-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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