Neutralizing antibody-dependent and -independent immune responses against SARS-CoV-2 in cynomolgus macaques

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorIshigaki, Hirohito-
Autor(es): dc.creatorNakayama, Misako-
Autor(es): dc.creatorKitagawa, Yoshinori-
Autor(es): dc.creatorNguyen, Cong Thanh-
Autor(es): dc.creatorHayashi, Kaori-
Autor(es): dc.creatorShiohara, Masanori-
Autor(es): dc.creatorGotoh, Bin-
Autor(es): dc.creatorItoh, Yasushi-
Data de aceite: dc.date.accessioned2026-02-09T12:10:20Z-
Data de disponibilização: dc.date.available2026-02-09T12:10:20Z-
Data de envio: dc.date.issued2021-01-04-
Data de envio: dc.date.issued2021-01-04-
Data de envio: dc.date.issued2021-01-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/45974-
Fonte completa do material: dc.identifierhttps://www.sciencedirect.com/science/article/pii/S0042682220302609#!-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1155858-
Descrição: dc.descriptionWe examined the pathogenicity of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in cynomolgus macaques for 28 days to establish an animal model of COVID-19 for the development of vaccines and antiviral drugs. Cynomolgus macaques infected with SARS-CoV-2 showed body temperature rises and X-ray radiographic pneumonia without life-threatening clinical signs of disease. A neutralizing antibody against SARS-CoV-2 and T-lymphocytes producing interferon (IFN)-γ specifically for SARS-CoV-2 N-protein were detected on day 14 in one of three macaques with viral pneumonia. In the other two macaques, in which a neutralizing antibody was not detected, T-lymphocytes producing IFN-γ specifically for SARS-CoV-2 N protein increased on day 7 to day 14, suggesting that not only a neutralizing antibody but also cellular immunity has a role in the elimination of SARS-CoV-2. Thus, because of similar symptoms to approximately 80% of patients, cynomolgus macaques are appropriate to extrapolate the efficacy of vaccines and antiviral drugs for humans.-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceVirology-
Palavras-chave: dc.subjectCOVID-19-
Palavras-chave: dc.subjectCoronavirus-
Palavras-chave: dc.subjectSARS-CoV-2-
Palavras-chave: dc.subjectNeutralizing antibody-
Palavras-chave: dc.subjectAnticorpo neutralizante-
Título: dc.titleNeutralizing antibody-dependent and -independent immune responses against SARS-CoV-2 in cynomolgus macaques-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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