Obesity-like metabolic effects of high-carbohydrate or high-fat diets consumption in metabolic and renal functions

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorCastro, Isabela Coelho de-
Autor(es): dc.creatorPequito, Danielle Cristina Tonello-
Autor(es): dc.creatorBorghetti, Gina-
Autor(es): dc.creatorYamaguchi, Adriana Aya-
Autor(es): dc.creatorBrito, Gleisson Alisson Pereira de-
Autor(es): dc.creatorYamazaki, Ricardo Key-
Autor(es): dc.creatorPôrto, Laura Cristina Jardim-
Autor(es): dc.creatorCoimbra, Terezila Machado-
Autor(es): dc.creatorFernandes, Luiz Claudio-
Autor(es): dc.creatorFernandez, Ricardo-
Data de aceite: dc.date.accessioned2026-02-09T12:07:57Z-
Data de disponibilização: dc.date.available2026-02-09T12:07:57Z-
Data de envio: dc.date.issued2022-02-09-
Data de envio: dc.date.issued2022-02-09-
Data de envio: dc.date.issued2020-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/49257-
Fonte completa do material: dc.identifierhttps://www.tandfonline.com/doi/abs/10.1080/13813455.2021.1874019?journalCode=iarp20-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1155003-
Descrição: dc.descriptionPresent study investigated which diet, high-carbohydrate (HCD) or high-fat (HFD), most effectively induces classical characteristics of obesity in mice. Mice were fed commercial chow (control), an HCD, or an HFD for 12 weeks. HFD and HCD increased body weight, fat mass, and glycaemia, whereas the HFD augmented insulinemia. In the kidney, the HFD caused albuminuria, and reductions in fractional Na+ excretion, Thromboxane B2 (TXB2) excretion, and urinary flow, whereas the HCD reduced glomerular filtration, plasma osmolality, and TXB2 and Prostaglandin E2 excretion. The consumption of HFD and HCD modified parameters that indicate histopathological changes, such as proliferation (proliferating-cell-nuclear antigen), inflammation (c-Jun N-terminal-protein), and epithelial-mesenchymal transition (vimentin, and desmin) in renal tissue, but the HCD group presents fewer signals of glomerular hypertrophy or tubule degeneration. In summary, the HCD generated the metabolic and renal changes required for an obesity model, but with a delay in the development of these modifications concerning the HFD.-
Idioma: dc.languageen-
Publicador: dc.publisherTaylor and Francis Online-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceArchives of Physiology and Biochemistry-
Palavras-chave: dc.subjectRenal function-
Palavras-chave: dc.subjectInflammation-
Palavras-chave: dc.subjectObesity-
Palavras-chave: dc.subjectHigh-fat diet-
Palavras-chave: dc.subjectEpithelial-mesenchymal transition-
Título: dc.titleObesity-like metabolic effects of high-carbohydrate or high-fat diets consumption in metabolic and renal functions-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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