Analgesic and anti-Inflammatory activities of the 2,8-dihydroxy-1,6-dimethoxyxanthone from Haploclathra paniculata (mart) benth (guttiferae)

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorMoreira, Maria Eliza Castro-
Autor(es): dc.creatorPereira, Rosemary Gualberto Fonseca Alvarenga-
Autor(es): dc.creatorSilva, Marcelo Jose Dias-
Autor(es): dc.creatorDias, Danielle Ferreira-
Autor(es): dc.creatorGontijo, Vanessa Silva-
Autor(es): dc.creatorGiusti-Paiva, Alexandre-
Autor(es): dc.creatorVeloso, Marcia Paranho-
Autor(es): dc.creatorDoriguetto, Antônio Carlos-
Autor(es): dc.creatorNagem, Tanus Jorge-
Autor(es): dc.creatorSantos, Marcelo Henrique dos-
Data de aceite: dc.date.accessioned2026-02-09T12:07:09Z-
Data de disponibilização: dc.date.available2026-02-09T12:07:09Z-
Data de envio: dc.date.issued2016-03-17-
Data de envio: dc.date.issued2016-03-17-
Data de envio: dc.date.issued2014-06-12-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/10924-
Fonte completa do material: dc.identifierhttp://online.liebertpub.com/doi/abs/10.1089/jmf.2013.0122-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1154705-
Descrição: dc.descriptionIn the present study, the pharmacological effects of 2,8-dihydroxy-1,6-dimethoxyxanthone from the bark of Haploclathra paniculata were investigated in mice using in vivo inflammation and nociception models. Acetic acid-induced writhing, paw licking induced by formalin, hot plate, and carrageenan-induced paw edema tests were used to investigate the anti-inflammatory and antinociceptive activities of the xanthone compound. Xanthone, at both doses, inhibited abdominal writhing and the formalin test. At a dose of 20 mg/kg, the time of reaction to the hot plate increased, and significant effects were observed after 30, 60 and 90 min of treatment. At doses of 10 and 20 mg/kg p.o., the 2,8-dihydroxy-1,6-dimethoxyxanthone significantly reduced paw edema at 3 h after the stimulus. The tests also showed no acute toxicity of the xanthone compound in mice. 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging ability was also studied and confirmed the antioxidant activity of the xanthone. To propose the mechanism of action of anti-inflammatory activity of the xanthone, a molecular docking was performed using the isoenzymes cyclooxygenase 1 and 2 and the results indicate that the molecule is capable of inhibiting both the enzymes. Therefore, it can be concluded that 2,8-dihydroxy-1,6-dimethoxyxanthone from H. paniculata demonstrates analgesic, anti-inflammatory, and antioxidant activities.-
Idioma: dc.languageen-
Publicador: dc.publisherMary Ann Liebert-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceJournal of Medicinal Food-
Palavras-chave: dc.subjectAnalgesic effect-
Palavras-chave: dc.subjectAnti-inflammatory activity-
Palavras-chave: dc.subjectEdema-
Palavras-chave: dc.subjectInflammation-
Palavras-chave: dc.subjectOxygenated xanthone-
Título: dc.titleAnalgesic and anti-Inflammatory activities of the 2,8-dihydroxy-1,6-dimethoxyxanthone from Haploclathra paniculata (mart) benth (guttiferae)-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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