Design of a novel multi epitope-based vaccine for pandemic Coronavirus Disease (COVID-19) by vaccinomics and probable prevention strategy against avenging zoonotics

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorAhmad, Sajjad-
Autor(es): dc.creatorNavid, Afifa-
Autor(es): dc.creatorFarid, Rabia-
Autor(es): dc.creatorAbbas, Ghulam-
Autor(es): dc.creatorAhmad, Faisal-
Autor(es): dc.creatorZaman, Naila-
Autor(es): dc.creatorParvaiz, Nousheen-
Autor(es): dc.creatorAzam, Syed Sikander-
Data de aceite: dc.date.accessioned2026-02-09T12:04:35Z-
Data de disponibilização: dc.date.available2026-02-09T12:04:35Z-
Data de envio: dc.date.issued2020-05-27-
Data de envio: dc.date.issued2020-05-27-
Data de envio: dc.date.issued2020-08-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/41245-
Fonte completa do material: dc.identifierhttp://www.sciencedirect.com/science/article/pii/S0928098720301767-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1153792-
Descrição: dc.descriptionThe emergence and rapid expansion of the coronavirus disease (COVID-19) require the development of effective countermeasures especially a vaccine to provide active acquired immunity against the virus. This study presented a comprehensive vaccinomics approach applied to the complete protein data published so far in the National Center for Biotechnological Information (NCBI) coronavirus data hub. We identified non-structural protein 8 (Nsp8), 3C-like proteinase, and spike glycoprotein as potential targets for immune responses to COVID-19. Epitopes prediction illustrated both B-cell and T-cell epitopes associated with the mentioned proteins. The shared B and T-cell epitopes: DRDAAMQRK and QARSEDKRA of Nsp8, EDMLNPNYEDL and EFTPFDVVR of 3C-like proteinase, and VNNSYECDIPI of the spike glycoprotein are regions of high potential interest and have a high likelihood of being recognized by the human immune system. The vaccine construct of the epitopes shows stimulation of robust primary immune responses and high level of interferon gamma. Also, the construct has the best conformation with respect to the tested innate immune receptors involving vigorous molecular mechanics and solvation energy. Designing of vaccination strategies that target immune response focusing on these conserved epitopes could generate immunity that not only provide cross protection across Betacoronaviruses but additionally resistant to virus evolution.-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceEuropean Journal of Pharmaceutical Sciences-
Palavras-chave: dc.subjectCOVID-19-
Palavras-chave: dc.subjectVaccinomics-
Palavras-chave: dc.subjectNon-structural protein 8-
Palavras-chave: dc.subject3C-like proteinase-
Palavras-chave: dc.subjectSpike glycoprotein-
Título: dc.titleDesign of a novel multi epitope-based vaccine for pandemic Coronavirus Disease (COVID-19) by vaccinomics and probable prevention strategy against avenging zoonotics-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

Não existem arquivos associados a este item.