N-methyl-D-aspartate receptors in the insular cortex modulate baroreflex in unanesthetized rats

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorAlves, Fernando H. F.-
Autor(es): dc.creatorCrestani, Carlos C.-
Autor(es): dc.creatorResstel, Leonardo B. M.-
Autor(es): dc.creatorCorrea, Fernando M. A.-
Data de aceite: dc.date.accessioned2026-02-09T12:01:57Z-
Data de disponibilização: dc.date.available2026-02-09T12:01:57Z-
Data de envio: dc.date.issued2018-05-15-
Data de envio: dc.date.issued2018-05-15-
Data de envio: dc.date.issued2009-05-11-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/29205-
Fonte completa do material: dc.identifierhttp://www.autonomicneuroscience.com/article/S1566-0702(09)00008-3/fulltext-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1152842-
Descrição: dc.descriptionIn the present study, we report the effect of insular cortex (IC) ablation caused by bilateral microinjection of the non-selective synaptic blocker CoCl2 on cardiac baroreflex response in unanesthetized rats as well as the involvement of local glutamatergic neurotransmission. Unilateral (left or right) microinjection of CoCl2 (1 nmol/ 100 nL) did not affect the bradycardiac response to blood pressure increase evoked by intravenous infusion of phenylephrine nor the tachycardiac response to blood pressure decrease caused by intravenous infusion of sodium nitroprusside, 10 min after CoCl2. Bilateral microinjection of CoCl2 into IC decreased the magnitude of reflex bradycardia without affecting tachycardiac responses. Baroreflex activity returned to control values 60 min after CoCl2 microinjection, confirming its reversible effect. Further we studied the possible involvement of IC-glutamatergic neurotransmission in baroreflex modulation. We observed that bilateral microinjection of the selective NMDA receptor antagonist LY235959 (4 nmol/100 nL) into the IC decreased the magnitude of reflex bradycardia without affecting tachycardiac responses. IC treatment with the selective non-NMDA antagonist NBQX (4 nmol/100 nL) did not affect baroreflex activity. The results suggest that synapses within the IC have a tonic excitatory influence on the baroreflex parasympathetic component. Moreover, the present data suggest that local NMDA-receptors are involved in the ICmediated tonic excitatory influence on baroreflex parasympathetic activity.-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceAutonomic Neuroscience: Basic and Clinical-
Palavras-chave: dc.subjectPrefrontal cortex-
Palavras-chave: dc.subjectGlutamatergic neurotransmission-
Palavras-chave: dc.subjectNMDA receptor-
Palavras-chave: dc.subjectCardiovascular system-
Palavras-chave: dc.subjectBaroreflex-
Palavras-chave: dc.subjectBlood pressure-
Palavras-chave: dc.subjectHeart rate-
Palavras-chave: dc.subjectCórtex pré-frontal-
Palavras-chave: dc.subjectNeurotransmissão glutamatérgica-
Palavras-chave: dc.subjectReceptor NMDA-
Palavras-chave: dc.subjectSistema cardiovascular-
Palavras-chave: dc.subjectBarorreflexo-
Palavras-chave: dc.subjectPressão sanguínea-
Palavras-chave: dc.subjectFrequência cardíaca-
Título: dc.titleN-methyl-D-aspartate receptors in the insular cortex modulate baroreflex in unanesthetized rats-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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