In silico interactions of the components from the Schinus terebinthifolius extract with human Tyrosinase

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorBezerra, Julia N.-
Autor(es): dc.creatorSpadeto, João Paulo M.-
Autor(es): dc.creatorDaré, Joyce K.-
Autor(es): dc.creatorAlmeida, Wanda Pereira-
Autor(es): dc.creatorFreitas, Matheus P.-
Autor(es): dc.creatorCormanich, Rodrigo A.-
Data de aceite: dc.date.accessioned2026-02-09T12:01:24Z-
Data de disponibilização: dc.date.available2026-02-09T12:01:24Z-
Data de envio: dc.date.issued2022-11-08-
Data de envio: dc.date.issued2022-11-08-
Data de envio: dc.date.issued2022-08-03-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/55454-
Fonte completa do material: dc.identifierhttps://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cplu.202200109-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1152636-
Descrição: dc.descriptionThe anti-tyrosinaseactivityof the leaf extractofSchinusterebinthifolius,also knownas Brazilianpeppertree,was eval-uated using multiplein silicoapproaches,such as molecularhomology,moleculardocking,MM-GBSA,moleculardynamics,MM-PBSA,QSAR, and skin permeabilitypredictions.With thesecomputationaltools, the compoundsthat downregulatetyrosi-nase enzymeactivitycould be evaluated,and more potentmoleculescould be identified.The results indicatedthat variouscompounds,especiallyluteolin,are accountablefor the anti-tyrosinaseactivity ofS. terebinthifolius.For cosmeticapplication,furtherstudieswith luteolinare especiallyrecommended,forhavingpresenteda good performanceboth in theoreticalinhibition(30.92kJmol1) and skin permeability(LogKp=6.62 cm1).-
Idioma: dc.languageen-
Publicador: dc.publisherChemistry Europe-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceChemPlusChem-
Palavras-chave: dc.subjectSchinus terebinthifolius-
Palavras-chave: dc.subjectBrazilian peppertree-
Palavras-chave: dc.subjectLuteolin-
Título: dc.titleIn silico interactions of the components from the Schinus terebinthifolius extract with human Tyrosinase-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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