Synthesis and characterization of 159Gd-doped hydroxyapatite nanorods for bioapplications as theranostic systems

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorCipreste, Marcelo F.-
Autor(es): dc.creatorPeres, Anderson M.-
Autor(es): dc.creatorCotta, Alexandre A. C.-
Autor(es): dc.creatorAragón, Fermin H.-
Autor(es): dc.creatorAntunes, Alan de M.-
Autor(es): dc.creatorLeal, Alexandre S.-
Autor(es): dc.creatorMacedo, Waldemar A. A.-
Autor(es): dc.creatorSousa, Edésia M. B. de-
Data de aceite: dc.date.accessioned2026-02-09T12:01:23Z-
Data de disponibilização: dc.date.available2026-02-09T12:01:23Z-
Data de envio: dc.date.issued2018-07-13-
Data de envio: dc.date.issued2018-07-13-
Data de envio: dc.date.issued2016-09-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/29687-
Fonte completa do material: dc.identifierhttps://www.sciencedirect.com/science/article/pii/S0254058416304771-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1152631-
Descrição: dc.descriptionGadolinium-doped hydroxyapatite (HA-Gd) nanorods have become promisor theranostic nanoparticles for early stage cancers as radioisotope carriers able to act in the treatment and multi-imaging diagnosis by single photon emission computed tomography and magnetic resonance imaging systems. In this work, gadolinium-doped HA nanorods were synthesized aiming the use as theranostic system for osteosarcomas. The as-prepared HA-Gd nanorods were characterized by XRD with Rietveld refinement method, FTIR, XPS, ICP-AES, TEM, SEM, BET and VSM in order to investigate the physical-chemical, morphology, pore size distribution and magnetic properties. Moreover, phosphorous and gadolinium in the HA-Gd sample were activated by neutron capture, in a nuclear reactor, producing 32P and 159Gd radioisotopes, and the surfaces of these nanorods were functionalized with folic acid. The results indicate that Gd3+ are trapped in the HA nanorods crystal net showing great stability of the HA-Gd interaction. Gadolinium provide paramagnetic properties on HA nanorods and structural phosphorous and gadolinium can be activated to induced gamma and beta activity. The well succeeded production of 159Gd-32P-HA makes this material a promisor agent to act as a theranostic system.-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceMaterials Chemistry and Physics-
Palavras-chave: dc.subjectHydroxyapatite nanorods-
Palavras-chave: dc.subjectGadolinium-
Palavras-chave: dc.subjectNeutron activation-
Palavras-chave: dc.subjectTheranostic system-
Título: dc.titleSynthesis and characterization of 159Gd-doped hydroxyapatite nanorods for bioapplications as theranostic systems-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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