Improvement of the oral praziquantel anthelmintic effect by cyclodextrin complexation

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorJesus, Marcelo Bispo de-
Autor(es): dc.creatorPinto, Luciana de Mato Alves-
Autor(es): dc.creatorFraceto, Leonardo Fernandes-
Autor(es): dc.creatorMagalhães, Luiz Augusto-
Autor(es): dc.creatorZanotti-Magalhães, Eliana Maria-
Autor(es): dc.creatorPaula, Eneida de-
Data de aceite: dc.date.accessioned2026-02-09T12:00:43Z-
Data de disponibilização: dc.date.available2026-02-09T12:00:43Z-
Data de envio: dc.date.issued2020-02-06-
Data de envio: dc.date.issued2020-02-06-
Data de envio: dc.date.issued2010-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/38958-
Fonte completa do material: dc.identifierhttps://www.tandfonline.com/doi/abs/10.3109/10611860903131677-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1152397-
Descrição: dc.descriptionSchistosomiasis is a parasitic disease which kills a half million people per year, all over the world. Praziquantel (PZQ) is the drug-of-choice for schistosomiasis because of its effectiveness, ease of administration, and low cost. However, poor solubility restricts its delivery, especially via the oral route. In this study, we describe β-cyclodextrin (β-CD) complexation as an alternative to improve the PZQ bioavailability. Physicochemical analysis were performed to characterize the inclusion complex formed between PZQ and β-CD. Differential scanning calorimetry (DSC) thermograms and morphological analysis using scanning electronic microscopy (SEM) gave evidences of the complex formation. Diffusion NMR experiments allowed determination of the fraction of PZQ bound to β-CD (37%) and the association constant (941 ± 47 M−1). The in vivo evaluation of the complexation on the effect of PZQ was performed on mice infected with Schistosoma mansoni (BH strain); after 15 days of treatment with the PZQ:β-CD complex the efficacy, evaluated by the number of remaining alive worms, was 99%, against 59% elicited by plain PZQ.-
Idioma: dc.languageen-
Publicador: dc.publisherTaylor & Francis Ltd.-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceJournal of Drug Targeting-
Palavras-chave: dc.subjectPraziquantel-
Palavras-chave: dc.subjectCyclodextrin-
Palavras-chave: dc.subjectInclusion complex-
Palavras-chave: dc.subjectSchistosomiasis-
Título: dc.titleImprovement of the oral praziquantel anthelmintic effect by cyclodextrin complexation-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

Não existem arquivos associados a este item.