Coagulation modifiers targeting SARS-CoV-2 main protease Mpro for COVID-19 treatment

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorBiembengut, Ísis Venturi-
Autor(es): dc.creatorSouza, Tatiana de Arruda Campos Brasil de-
Data de aceite: dc.date.accessioned2026-02-09T11:59:16Z-
Data de disponibilização: dc.date.available2026-02-09T11:59:16Z-
Data de envio: dc.date.issued2020-05-14-
Data de envio: dc.date.issued2020-05-14-
Data de envio: dc.date.issued2020-04-17-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/40912-
Fonte completa do material: dc.identifierhttps://www.arca.fiocruz.br/bitstream/icict/40946/2/20_0179.pdf-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1151880-
Descrição: dc.descriptionSARS-CoV-2 infection depends on viral polyprotein processing, an event catalyzed by the main proteinase Mpro. The solution of the SARS-CoV-2 Mpro tridimensional structure in the last month allowed the investigation of potential inhibitors of viral replication. As objective, this work aims to provide first evidences of the applicability of commercial y approved drugs to treat COVID-19. As methods used in this research: We screened 4,334 compounds to found potential inhibitors of SARS-CoV-2 replication using an in silico approach. Thereby we have as findings that, The higher scores interactions include antiviral components and drugs classified as coagulation modifiers, ACE and dipeptidyl peptidase 4 inhibitors, antimigraine agents, antihistamine. And finally as main conclusions: Our result evidenced the potential use of coagulation modifiers in COVID-19 treatment due to the structural similarity of SARS-CoV main protease Mpro and human coagulation factors thrombin and Factor Xa.-
Idioma: dc.languagept_BR-
Publicador: dc.publisherFundação Oswaldo Cruz. Instituto Oswaldo Cruz-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceMemórias do Instituto Oswaldo Cruz-
Palavras-chave: dc.subjectCOVID-19-
Palavras-chave: dc.subjectCoronavirus-
Palavras-chave: dc.subjectSARS-CoV-2-
Palavras-chave: dc.subjectIn silico approach-
Palavras-chave: dc.subjectProteínas de Transporte-
Título: dc.titleCoagulation modifiers targeting SARS-CoV-2 main protease Mpro for COVID-19 treatment-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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