Prognostic value of interleukin-6, C-reactive protein, and procalcitonin in patients with COVID-19

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorLiu, Fang-
Autor(es): dc.creatorLi, Lin-
Autor(es): dc.creatorXu, MengDa-
Autor(es): dc.creatorWu, Juan-
Autor(es): dc.creatorLuo, Ding-
Autor(es): dc.creatorZhu, YuSi-
Autor(es): dc.creatorLi, BiXi-
Autor(es): dc.creatorSong, XiaoYang-
Autor(es): dc.creatorZhou, Xiang-
Data de aceite: dc.date.accessioned2026-02-09T11:57:49Z-
Data de disponibilização: dc.date.available2026-02-09T11:57:49Z-
Data de envio: dc.date.issued2020-09-17-
Data de envio: dc.date.issued2020-09-17-
Data de envio: dc.date.issued2020-06-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/43115-
Fonte completa do material: dc.identifierhttps://www.sciencedirect.com/science/article/abs/pii/S1386653220301128-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1151336-
Descrição: dc.descriptionBackground The inflammatory response plays a critical role in coronavirus disease 2019 (COVID-19), and inflammatory cytokine storm increases the severity of COVID-19. Objective To investigate the ability of interleukin-6 (IL-6), C-reactive protein (CRP), and procalcitonin (PCT) to predict mild and severe cases of COVID-19. Study design This retrospective cohort study included 140 patients diagnosed with COVID-19 from January 18, 2020, to March 12, 2020. The study population was divided into two groups according to disease severity: a mild group (MG) (n = 107) and a severe group (SG) (n = 33). Data on demographic characteristics, baseline clinical characteristics, and the levels of IL-6, CRP, and PCT on admission were collected. Results Among the 140 patients, the levels of IL-6, CRP, and PCT increased in 95 (67.9 %), 91 (65.0 %), and 8 (5.7 %) patients on admission, respectively. The proportion of patients with increased IL-6, CRP, and PCT levels was significantly higher in the SG than in the MG. Cox proportional hazard model showed that IL-6 and CRP could be used as independent factors to predict the severity of COVID-19. Furthermore, patients with IL-6 > 32.1 pg/mL or CRP > 41.8 mg/L were more likely to have severe complications. Conclusion The serum levels of IL-6 and CRP can effectively assess disease severity and predict outcome in patients with COVID-19.-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceJournal of Clinical Virology-
Palavras-chave: dc.subjectCOVID-19-
Palavras-chave: dc.subjectInterleukin-6-
Palavras-chave: dc.subjectC-reactive protein-
Palavras-chave: dc.subjectProcalcitonin-
Palavras-chave: dc.subjectPrognosis-
Título: dc.titlePrognostic value of interleukin-6, C-reactive protein, and procalcitonin in patients with COVID-19-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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