Molecular modeling of Mycobacterium tuberculosis DNA gyrase and its molecular docking study with gatifloxacin inhibitors

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorCunha, Elaine F. F. da-
Autor(es): dc.creatorBarbosa, Edilaine F.-
Autor(es): dc.creatorOliveira, Aline A.-
Autor(es): dc.creatorRamalho, Teodorico C.-
Data de aceite: dc.date.accessioned2026-02-09T11:57:40Z-
Data de disponibilização: dc.date.available2026-02-09T11:57:40Z-
Data de envio: dc.date.issued2018-01-26-
Data de envio: dc.date.issued2018-01-26-
Data de envio: dc.date.issued2010-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/28456-
Fonte completa do material: dc.identifierhttp://www.tandfonline.com/doi/abs/10.1080/07391102.2010.10508576-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1151282-
Descrição: dc.descriptionMycobacterium tuberculosis (Mt) is a leading cause of infectious disease in the world today. This outlook is aggravated by a growing number of Mt infections in individuals who are immunocompromised as a result of HIV infections. Thus, new and more potent anti-tuberculosis agents are necessary. Therefore, DNA gyrase was selected as a target enzyme to combat Mt. In this work, the first three-dimensional molecular model of the hypothetical structures for the Mycobacterium tuberculosis DNA gyrase (mtDNAg) was elucidated by a homology modeling method. In addition, the orientations and binding affinities of some gatifloxacin analogs with those new structures were investigated. Our findings could be helpful for the design of new more potent gatifloxacin analogs.-
Idioma: dc.languageen-
Publicador: dc.publisherTaylor & Francis-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceJournal of Biomolecular Structure and Dynamics-
Palavras-chave: dc.subjectHomology modeling-
Palavras-chave: dc.subjectDNA gyrase-
Palavras-chave: dc.subjectMycobacterium tuberculosis-
Palavras-chave: dc.subjectDocking-
Palavras-chave: dc.subjectModelagem de homologia-
Palavras-chave: dc.subjectDNA girase-
Palavras-chave: dc.subjectDocagem-
Título: dc.titleMolecular modeling of Mycobacterium tuberculosis DNA gyrase and its molecular docking study with gatifloxacin inhibitors-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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