Activity of chalcones derived from 2,4,5-trimethoxybenzaldehyde against Meloidogyne exigua and in silico interaction of one chalcone with a putative caffeic acid 3-O-methyltransferase from Meloidogyne incognita

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorNunes, Alexandro Silva-
Autor(es): dc.creatorCampos, Vicente Paulo-
Autor(es): dc.creatorMascarello, Alessandra-
Autor(es): dc.creatorStumpf, Taisa Regina-
Autor(es): dc.creatorChiaradia-Delatorre, Louise Domenghini-
Autor(es): dc.creatorMachado, Alan Rodrigues Teixeira-
Autor(es): dc.creatorSantos Júnior, Helvécio Martins-
Autor(es): dc.creatorYunes, Rosendo Augusto-
Autor(es): dc.creatorNunes, Ricardo José-
Autor(es): dc.creatorOliveira, Denilson Ferreira-
Data de aceite: dc.date.accessioned2026-02-09T11:56:23Z-
Data de disponibilização: dc.date.available2026-02-09T11:56:23Z-
Data de envio: dc.date.issued2017-10-11-
Data de envio: dc.date.issued2017-10-11-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/15508-
Fonte completa do material: dc.identifierhttp://www.sciencedirect.com/science/article/pii/S0014489413002683?via%3Dihub-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1150797-
Descrição: dc.descriptionMeloidogyne exigua is a parasitic nematode of plants that causes great losses to coffee farmers. In an effort to develop parasitic controls, 154 chalcones were synthesized and screened for activity against this nematode. The best results were obtained with (2E)-1-(4′-nitrophenyl)-3-(2,4,5-trimethoxyphenyl)prop-2-en-1-one (6) with a 50% lethal concentration (LC50) of 171 μg/ml against M. exigua second-stage juveniles, in comparison to the commercially-available nematicide carbofuran which had an LC50 of 260 μg/ml under the same conditions. When coffee plants were used, 6 reduced the nematode population to ∼50% of that observed in control plants. To investigate the mechanism of action of 6, an in silico study was carried out, which indicated that 6 may act against M. exigua through inhibition of a putative caffeic acid 3-O-methyltransferase homodimer, the amino acid sequence of which was determined by examining the genome of Meloidogyne incognita.-
Descrição: dc.descriptionhttps://repositorio.ufla.br/handle/1/15508-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceExperimental Parasitology-
Palavras-chave: dc.subjectNematicide-
Palavras-chave: dc.subjectRoot-knot nematode-
Palavras-chave: dc.subjectMeloidogyne-
Palavras-chave: dc.subjectProtein modeling-
Palavras-chave: dc.subjectChalcone-
Palavras-chave: dc.subjectNematicida-
Palavras-chave: dc.subjectNematodo de nó de raiz-
Palavras-chave: dc.subjectModelagem de proteínas-
Título: dc.titleActivity of chalcones derived from 2,4,5-trimethoxybenzaldehyde against Meloidogyne exigua and in silico interaction of one chalcone with a putative caffeic acid 3-O-methyltransferase from Meloidogyne incognita-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

Não existem arquivos associados a este item.