Carbohydrate-enriched diet impairs cardiac performance by decreasing the utilization of fatty acid and glucose

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorPôrto, L. C. J.-
Autor(es): dc.creatorSavergnini, S. S.Q.-
Autor(es): dc.creatorCastro, C. H.-
Autor(es): dc.creatorMario, É. G.-
Autor(es): dc.creatorFerreira, A. V.M.-
Autor(es): dc.creatorSantos, S. H.S.-
Autor(es): dc.creatorAndrade, S. P.-
Autor(es): dc.creatorSantos, R. A.S.-
Autor(es): dc.creatorAlmeida, A. P.-
Autor(es): dc.creatorBotion, L. M.-
Data de aceite: dc.date.accessioned2026-02-09T11:53:19Z-
Data de disponibilização: dc.date.available2026-02-09T11:53:19Z-
Data de envio: dc.date.issued2015-07-20-
Data de envio: dc.date.issued2015-07-20-
Data de envio: dc.date.issued2011-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/9698-
Fonte completa do material: dc.identifierhttp://tak.sagepub.com/content/5/1/11-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1149660-
Descrição: dc.descriptionAims: We hypothesized that a high-carbohydrate diet affects the cardiac performance by interfering in the metabolic steps involved in energy transfer in this organ. To verify this, we investigated the myocardial utilization of different substrates and contractile function in rats fed a high-carbohydrate diet, under normal flow and ischemia. Methods and Results: Male Wistar rats were fed over 9 days with standard (39.5% carbohydrate, 8% fiber) or high-carbohydrate diet (58% carbohydrate) and, afterwards, their cardiac function was examined using isolated heart preparations. The high-carbohydrate diet decreased the activity of the lipoprotein lipase, utilization of fatty acids, expression of the gene of peroxisome proliferator-activated receptor a and its target enzymes. In addition, decreased GLUT4 mass, glucose uptake, glycogen content and glycolytic intermediates were also observed. High-carbohydrate hearts displayed weaker activation of the glycolytic pathway during ischemia, according to minor production of lactate, in relation to control hearts. The functional impairment caused by high-carbohydrate diet shown by the decrease in the ventricular systolic strength, +dT/dt and ÀdT/dt was, at least in part, due to the low availability of adenosine triphosphate (ATP). Conclusion: Our data suggest that a high-carbohydrate diet can damage myocardial contractile function by decreasing the cardiac utilization of glucose and fatty acids and, consequently, the ATP pool.-
Idioma: dc.languageen-
Publicador: dc.publisherCommittee on Publication Ethics (COPE)-
Direitos: dc.rightsrestrito-
???dc.source???: dc.sourceTherapeutic Advances in Cardiovascular Disease-
Palavras-chave: dc.subjectCardiac tissue-
Palavras-chave: dc.subjectEnergetic metabolism-
Palavras-chave: dc.subjectFatty acid-
Palavras-chave: dc.subjectHigh carbohydrate diet-
Palavras-chave: dc.subjectGlucose-
Título: dc.titleCarbohydrate-enriched diet impairs cardiac performance by decreasing the utilization of fatty acid and glucose-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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