Inhibition by essential oils of Mentha viridis and Mentha pulegium (Lamiaceae) in proteolysis, fibrinogenolysis and coagulation caused by venomous snakes

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorMarcussi, Silvana-
Autor(es): dc.creatorSilva, Lucilene Fernandes-
Autor(es): dc.creatorBraga, Mariana Aparecida-
Autor(es): dc.creatorEspósito, Mariana Araújo-
Autor(es): dc.creatorCesar, Pedro Henrique Souza-
Data de aceite: dc.date.accessioned2026-02-09T11:52:37Z-
Data de disponibilização: dc.date.available2026-02-09T11:52:37Z-
Data de envio: dc.date.issued2020-05-18-
Data de envio: dc.date.issued2020-05-18-
Data de envio: dc.date.issued2019-09-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/41023-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1149415-
Descrição: dc.descriptionSnake venoms are widely used as laboratory tools for studies of physiological, pharmacological and toxicological mechanisms. Venoms used here are rich sources of several classes of proteases that act on factors of the coagulation cascade, fibrinogenolysis and fibrinolysis, altering the hemostatic processes, and phospholi-pases A2 which are involved mainly in inflammatory and clotting processes. Natural products such as essential oils are made up of active ingredients with wide application in the food, pharmaceutical and cosmetic industries. Thus, this study evaluates the essential oils from Mentha viridis and Mentha pulegium on coagulation, fibrinoge-nolysis and degradation of azocasein, induced by Bothrops sp and Lachesis mutamuta venoms. These oils were achieved by hydrodistillation and presented, respectively, as the main constituents linalool (40.70 %), carvone (13.52 %) and α-terpinene (8.56 %); pulegone (50.01 %), menthol (31.90 %) and menthone (16.56 %). The essential oils were previously incubated with Bothrops alternatus venom, for two different times, then plasma was added and time was recorded. The M. viridis oil presented greater anticlotting potential. Meanwhile, the M. pulegium oil presented anticlotting or proclotting activity dependent on the dose tested. The incubation time also influenced the effect of the oils on the coagulation time. At azocaseinolytic assay, the oil from M. pulegiumreduced the activity for all evaluated venoms. The highest inhibition was of 39.99 %; on activity induced by B. jararacussu, M. viridis reduced the activity in 57.72 %. On B. moojeni, the major inhibition observed was of 74.67 %. The fibrinogenolysis induced by B. moojeni venom was totally inhibited by both oils in the evaluated proportions. The results show the presence in oils of protease inhibitors, considering serine and metalloprote-ases (acting on clotting factors or with hemorrhagic activity), as well as phospholipase A2 (enzymes involved in inflammation and clotting processes) inhibitors of wide application in medical and biotechnology areas.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Publicador: dc.publisherUniversidad de Costa Rica-
Direitos: dc.rightsacesso aberto-
Direitos: dc.rightshttp://creativecommons.org/licenses/by/4.0/-
Direitos: dc.rightshttp://creativecommons.org/licenses/by/4.0/-
???dc.source???: dc.sourceRevista de Biologia Tropical-
Palavras-chave: dc.subjectBothrops-
Palavras-chave: dc.subjectLachesis-
Palavras-chave: dc.subjectProtease inhibition-
Palavras-chave: dc.subjectEssential oil-
Palavras-chave: dc.subjectNatural compounds-
Palavras-chave: dc.subjectAntiophidian properties-
Título: dc.titleInhibition by essential oils of Mentha viridis and Mentha pulegium (Lamiaceae) in proteolysis, fibrinogenolysis and coagulation caused by venomous snakes-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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