A pneumonia outbreak associated with a new coronavirus of probable bat origin

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Autor(es): dc.creatorZhou, Peng-
Autor(es): dc.creatorYang, Xing-Lou-
Autor(es): dc.creatorWang, Xian-Guang-
Autor(es): dc.creatorHu, Ben-
Autor(es): dc.creatorZhang, Lei-
Autor(es): dc.creatorZhang, Wei-
Autor(es): dc.creatorSi, Hao-Rui-
Autor(es): dc.creatorZhu, Yan-
Autor(es): dc.creatorLi, Bei-
Autor(es): dc.creatorHuang, Chao-Lin-
Autor(es): dc.creatorChen, Hui-Dong-
Autor(es): dc.creatorChen, Jing-
Autor(es): dc.creatorLuo, Yun-
Autor(es): dc.creatorGuo, Hua-
Autor(es): dc.creatorJiang, Ren-Di-
Autor(es): dc.creatorLiu, Mei-Qin-
Autor(es): dc.creatorChen, Ying-
Autor(es): dc.creatorShen, Xu-Rui-
Autor(es): dc.creatorWang, Xi-
Autor(es): dc.creatorZheng, Xiao-Shuang-
Autor(es): dc.creatorZhao, Kai-
Autor(es): dc.creatorChen, Quan-Jiao-
Autor(es): dc.creatorDeng, Fei-
Autor(es): dc.creatorLiu, Lin-Lin-
Autor(es): dc.creatorYan, Bing-
Autor(es): dc.creatorZhan, Fa-Xian-
Autor(es): dc.creatorWang, Yan-Yi-
Autor(es): dc.creatorXiao, Geng-Fu-
Autor(es): dc.creatorShi, Zheng-Li-
Data de aceite: dc.date.accessioned2026-02-09T11:52:03Z-
Data de disponibilização: dc.date.available2026-02-09T11:52:03Z-
Data de envio: dc.date.issued2020-03-26-
Data de envio: dc.date.issued2020-03-26-
Data de envio: dc.date.issued2019-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/39411-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1149201-
Descrição: dc.descriptionSince the outbreak of severe acute respiratory syndrome (SARS) 18 years ago, a large number of SARS-related coronaviruses (SARSr-CoVs) have been discovered in their natural reservoir host, bats1,2,3,4. Previous studies have shown that some bat SARSr-CoVs have the potential to infect humans5,6,7. Here we report the identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China. The epidemic, which started on 12 December 2019, had caused 2,794 laboratory-confirmed infections including 80 deaths by 26 January 2020. Full-length genome sequences were obtained from five patients at an early stage of the outbreak. The sequences are almost identical and share 79.6% sequence identity to SARS-CoV. Furthermore, we show that 2019-nCoV is 96% identical at the whole-genome level to a bat coronavirus. Pairwise protein sequence analysis of seven conserved non-structural proteins domains show that this virus belongs to the species of SARSr-CoV. In addition, 2019-nCoV virus isolated from the bronchoalveolar lavage fluid of a critically ill patient could be neutralized by sera from several patients. Notably, we confirmed that 2019-nCoV uses the same cell entry receptor—angiotensin converting enzyme II (ACE2)—as SARS-CoV.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Publicador: dc.publisherSpringer Nature-
Direitos: dc.rightsAttribution 4.0 International-
Direitos: dc.rightsAttribution 4.0 International-
Direitos: dc.rightsacesso aberto-
Direitos: dc.rightshttp://creativecommons.org/licenses/by/4.0/-
Direitos: dc.rightshttp://creativecommons.org/licenses/by/4.0/-
???dc.source???: dc.sourceNature-
Palavras-chave: dc.subjectCoronavirus-
Palavras-chave: dc.subjectSevere acute respiratory syndrome-
Palavras-chave: dc.subjectPathogenic virus-
Palavras-chave: dc.subjectSíndrome respiratória aguda grave-
Palavras-chave: dc.subjectVírus patogênicos-
Título: dc.titleA pneumonia outbreak associated with a new coronavirus of probable bat origin-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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