Aerobic exercise inhibits acute lung injury: from mouse to human evidence Exercise reduced lung injury markers in mouse and in cells

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Autor(es): dc.creatorRigonato-Oliveira, Nicole Cristine-
Autor(es): dc.creatorMacKenzie, BreAnne-
Autor(es): dc.creatorBachi, Andre Luis Lacerda-
Autor(es): dc.creatorOliveira Junior, Manoel Carneiro-
Autor(es): dc.creatorSantos-Dias, Alana-
Autor(es): dc.creatorBrandao-Rangel, Maysa Alves Rodrigues-
Autor(es): dc.creatorDelle, Humberto-
Autor(es): dc.creatorCosta-Guimaraes, Tamara-
Autor(es): dc.creatorDamaceno-Rodrigues, Nilsa Regina-
Autor(es): dc.creatorDulley, Larissa Hilário-
Autor(es): dc.creatorBenetti, Marcela Anhesini-
Autor(es): dc.creatorMalfitano, Christiane-
Autor(es): dc.creatorAngelis, Kátia de-
Autor(es): dc.creatorAlbertini, Regiane-
Autor(es): dc.creatorOliveira, Ana Paula Ligeiro-
Autor(es): dc.creatorAbbasi, Asghar-
Autor(es): dc.creatorNorthoff, Hinnak-
Autor(es): dc.creatorVieira, Rodolfo Paula-
Data de aceite: dc.date.accessioned2026-02-09T11:50:43Z-
Data de disponibilização: dc.date.available2026-02-09T11:50:43Z-
Data de envio: dc.date.issued2019-02-27-
Data de envio: dc.date.issued2019-02-27-
Data de envio: dc.date.issued2018-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/33069-
Fonte completa do material: dc.identifierhttp://eir-isei.de/2018/eir-2018-036-article.pdf-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1148707-
Descrição: dc.descriptionAcute respiratory distress syndrome (ARDS) is defined as hypoxemic respiratory failure with intense pulmonary inflammation, involving hyperactivation of endothelial cells and neutrophils. Given the anti-inflammatory effects of aerobic exercise (AE), this study investigated whether AE performed daily for 5 weeks would inhibit extra-pulmonary LPS-induced ARDS. C57Bl/6 mice were distributed into Control, Exercise, LPS and Exercise+LPS groups. AE was performed on a treadmill for 5x/week for four weeks before LPS administration. 24hours after the final AE physical test, animals received 100ug of LPS intra-peritoneally. In addition, whole blood cell culture, neutrophils and human endothelial cells were preincubated with IL-10, an anti-inflammatory cytokine induced by exercise. AE reduced total protein levels (p<0.01) and neutrophil accumulation in bronchoalveolar lavage (BAL) (p<0.01) and lung parenchyma (p<0.01). AE reduced BAL inflammatory cytokines IL-1β, IL-6 and GM-CSF (p<0.001), CXCL1/KC, IL-17, TNF-alpha and IGF-1 (p<0.01). Systemically, AE reduced IL-1β, IL-6 and IFN-gamma (p<0.001), CXCL1/KC (p<0.01) and TNF-alpha (p<0.05). AE increased IL-10 levels in serum (p<0.001) and BAL (p<0.001). Furthermore, AE increased superoxide dismutase SOD (p<0.01) and decreased superoxide anion accumulation in the lungs (p<0.01). Lastly, pre-incubation with IL-10 significantly reduced LPS-induced activation of whole blood cells, neutrophils and HUVECs, as observed by reduced production of IL-1β, IL-6, IL-8 and TNF-alpha. Our data suggest that AE inhibited LPS-induced lung inflammation by attenuating inflammatory cytokines and oxidative stress markers in mice and human cell culture via enhanced IL-10 production.-
Idioma: dc.languageen-
Publicador: dc.publisherInternational Society of Exercise and Immunology-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceExercise Immunology-
Palavras-chave: dc.subjectExercise immunology-
Palavras-chave: dc.subjectLung inflammation-
Palavras-chave: dc.subjectImmune response-
Palavras-chave: dc.subjectAcute lung injury-
Palavras-chave: dc.subjectCytokines-
Palavras-chave: dc.subjectImunologia do exercício-
Palavras-chave: dc.subjectInflamação pulmonar-
Palavras-chave: dc.subjectResposta imune-
Palavras-chave: dc.subjectLesão pulmonar aguda-
Palavras-chave: dc.subjectCitocinas-
Título: dc.titleAerobic exercise inhibits acute lung injury: from mouse to human evidence Exercise reduced lung injury markers in mouse and in cells-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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