Aerobic exercise protects from Pseudomonas aeruginosa-induced pneumonia in elderly mice

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Autor(es): dc.creatorDurigon, Thomas Stravinskas-
Autor(es): dc.creatorMacKenzie, BreAnne-
Autor(es): dc.creatorOliveira-Junior, Manoel Carneiro-
Autor(es): dc.creatorSantos-Dias, Alana-
Autor(es): dc.creatorAngelis, Kátia de-
Autor(es): dc.creatorMalfitano, Christiano-
Autor(es): dc.creatorPalma, Renata Kelly da-
Autor(es): dc.creatorGuerra, Juliana Moreno-
Autor(es): dc.creatorDamaceno-Rodrigues, Nilsa Regina-
Autor(es): dc.creatorCaldini, Elia Garcia-
Autor(es): dc.creatorAlmeida, Francine Maria de-
Autor(es): dc.creatorAquino-Santos, Helida Cristina-
Autor(es): dc.creatorRigonato-Oliveira, Nicole Cristine-
Autor(es): dc.creatorOliveira, Danielle Bruna Leal de-
Autor(es): dc.creatorAimbire, Flavio-
Autor(es): dc.creatorOliveira, Ana Paula Ligeiro de-
Autor(es): dc.creatorOliveira, Luiz Vicente Franco de-
Autor(es): dc.creatorDurigon, Edison Luiz-
Autor(es): dc.creatorHiemstra, Pieter S.-
Autor(es): dc.creatorVieira, Rodolfo P.-
Data de aceite: dc.date.accessioned2026-02-09T11:50:00Z-
Data de disponibilização: dc.date.available2026-02-09T11:50:00Z-
Data de envio: dc.date.issued2019-02-27-
Data de envio: dc.date.issued2019-02-27-
Data de envio: dc.date.issued2018-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/33070-
Fonte completa do material: dc.identifierhttps://www.karger.com/Article/FullText/488953-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1148451-
Descrição: dc.descriptionBackground: Pseudomonas aeruginosa (PS) infection results in severe morbidity and mortality, especially in immune-deficient populations. Aerobic exercise (AE) modulates the immune system, but its effects on the outcomes of pulmonary PS infection in elderly mice are unknown. Methods: BALB/c mice (24 weeks old) were randomized to sedentary, exercise (EX), PS, and PS + EX groups for the acute experimental setting, and PS and PS + EX groups for the chronic setting. Low-intensity AE was performed for 5 weeks, 60 min/day; 24 h after the final AE session, mice were inoculated with 5 × 104 colony-forming units (CFU) of PS, and 24 h and 14 days after PS inoculation, mice were studied. Results: AE inhibited PS colonization (p < 0.001) and lung inflammation (total cells, neutrophils, lymphocytes [p < 0.01] in bronchoalveolar lavage [BAL]), with significant differences in BAL levels of IL-1β (p < 0.001), IL-6 (p < 0.01), CXCL1 (p < 0.001), and TNF-α (p < 0.001), as well as parenchymal neutrophils (p < 0.001). AE increased BAL levels of IL-10 and parenchymal (p < 0.001) and epithelial (p < 0.001) IL-10 expression, while epithelial (p < 0.001) and parenchymal (p < 0.001) NF-κB expression was decreased. AE diminished pulmonary lipid peroxidation (p < 0.001) and increased glutathione peroxidase (p < 0.01). Pre-incubation of BEAS-2B with IL-10 inhibited PS-induced epithelial cell expression of TNF-α (p < 0.05), CD40 (p < 0.01), and dichlorodihydrofluorescein diacetate (p < 0.05). Conclusions: AE inhibits PS-induced lung inflammation and bacterial colonization in elderly mice, involving IL-10/NF-κB, and redox signaling.-
Idioma: dc.languageen-
Publicador: dc.publisherKarger-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceJournal of Innate Immunity-
Palavras-chave: dc.subjectExercise immunology-
Palavras-chave: dc.subjectPseudomonas-
Palavras-chave: dc.subjectCytokines-
Palavras-chave: dc.subjectElderly-
Palavras-chave: dc.subjectPhysical training-
Palavras-chave: dc.subjectImunologia do exercício-
Palavras-chave: dc.subjectCitocinas-
Palavras-chave: dc.subjectTreinamento físico-
Palavras-chave: dc.subjectIdosos-
Título: dc.titleAerobic exercise protects from Pseudomonas aeruginosa-induced pneumonia in elderly mice-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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