Role of oxidized LDL-induced “trained macrophages” in the pathogenesis of COVID-19 and benefits of pioglitazone: a hypothesis

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorErol, Adnan-
Data de aceite: dc.date.accessioned2026-02-09T11:49:56Z-
Data de disponibilização: dc.date.available2026-02-09T11:49:56Z-
Data de envio: dc.date.issued2020-05-28-
Data de envio: dc.date.issued2020-05-28-
Data de envio: dc.date.issued2019-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/41267-
Fonte completa do material: dc.identifierhttp://www.sciencedirect.com/science/article/pii/S1871402120301260-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1148431-
Descrição: dc.descriptionBackground and aims Older adults and people who have cardiovascular disorders (their common pathogenetic mechanism is progressive atherosclerosis) are at higher risk for severe illness from COVID-19 (coronavirus disease 2019). Their common pathogenetic mechanism is progressive atherosclerosis in which oxLDL (oxidized LDL) plays major role. Receptor-mediated uptake of oxLDL by the monocyte-derived macrophages activates the long-term epigenetic reprogramming of innate immunity, which is termed “trained immunity.” The aim of this work is to investigate the mechanisms and treatment possibilities that can control the activities of these specific macrophages. Methods Search in Medline and PubMed relevant articles on the trained immunity and cytokine storm of COVID-19. Results and Conclusions When oxLDL-trained macrophages encounter SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) in the lung, it causes unregulated cytokine secretion, leading to the alveolar damage. Therefore, blocking macrophage training by pioglitazone, a thiazolidinedione, could control the hyperactivation that the virus would trigger.-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceDiabetes & Metabolic Syndrome: Clinical Research & Reviews-
Palavras-chave: dc.subjectCOVID-19-
Palavras-chave: dc.subjectMacrophage-
Palavras-chave: dc.subjectOxidized low-density lipoprotein (oxLDL)-
Palavras-chave: dc.subjectPioglitazone-
Título: dc.titleRole of oxidized LDL-induced “trained macrophages” in the pathogenesis of COVID-19 and benefits of pioglitazone: a hypothesis-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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