Anticoagulant and fibrinogenolytic properties of the venom of Polybia occidentalis social wasp

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorCzaikoski, Paula-
Autor(es): dc.creatorMenaldo, Danilo L.-
Autor(es): dc.creatorMarcussi, Silvana-
Autor(es): dc.creatorBaseggio, Anne L. C.-
Autor(es): dc.creatorFuly, André L.-
Autor(es): dc.creatorPaula, Rafael C.-
Autor(es): dc.creatorQuadros, Andreza U.-
Autor(es): dc.creatorRomão, Pedro R. T.-
Autor(es): dc.creatorBuschini, Maria L. T.-
Autor(es): dc.creatorCunha, Fernando Q.-
Autor(es): dc.creatorSoares, Andreimar M.-
Autor(es): dc.creatorMonteiro, Marta-
Data de aceite: dc.date.accessioned2026-02-09T11:49:18Z-
Data de disponibilização: dc.date.available2026-02-09T11:49:18Z-
Data de envio: dc.date.issued2020-05-18-
Data de envio: dc.date.issued2020-05-18-
Data de envio: dc.date.issued2010-10-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/40995-
Fonte completa do material: dc.identifierhttps://journals.lww.com/bloodcoagulation/Abstract/2010/10000/Anticoagulant_and_fibrinogenolytic_properties_of.6.aspx-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1148195-
Descrição: dc.descriptionPrevious studies have shown that venoms of social wasps and bees exhibit strong anticoagulant activity. The present study describes the anticoagulant and fibrinogen-degrading pharmacological properties of the venom of Polybia occidentalis social wasp. The results demonstrated that this venom presented anticoagulant effect, inhibiting the coagulation at different steps of the clotting pathway (intrinsic, extrinsic and common pathway). The venom inhibited platelet aggregation and degraded plasma fibrinogen, possibly containing metal-dependent metalloproteases that specifically cleave the Bβ-chain of fibrinogen. In conclusion, fibrinogenolytic and anticoagulant properties of this wasp venom find a potential application in drug development for the treatment of thrombotic disorders. For that, further studies should be carried out in order to identify and isolate the active compounds responsible for these effects.-
Idioma: dc.languageen-
Publicador: dc.publisherWolters Kluwer-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceBlood Coagulation & Fibrinolysis-
Palavras-chave: dc.subjectAnticoagulant activity-
Palavras-chave: dc.subjectFibrinogenolytic activity-
Título: dc.titleAnticoagulant and fibrinogenolytic properties of the venom of Polybia occidentalis social wasp-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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