Metabolic and behavioral effects of ractopamine at continuous low levels in rats under stress

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorLopes, Edna-
Autor(es): dc.creatorSousa, Raimundo Vicente de-
Autor(es): dc.creatorZangerônimo, Márcio Gilberto-
Autor(es): dc.creatorPereira, Andressa Naira de Jesus-
Autor(es): dc.creatorCoelho, Mariana de Resende-
Autor(es): dc.creatorFerreira, Matheus Soares da Silva-
Autor(es): dc.creatorLima, Renato Ribeiro-
Autor(es): dc.creatorMarcondes, Fernanda Klein-
Autor(es): dc.creatorNapimoga, Marcelo Henrique-
Autor(es): dc.creatorPereira, Luciano José-
Data de aceite: dc.date.accessioned2026-02-09T11:47:18Z-
Data de disponibilização: dc.date.available2026-02-09T11:47:18Z-
Data de envio: dc.date.issued2020-07-09-
Data de envio: dc.date.issued2020-07-09-
Data de envio: dc.date.issued2015-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/41779-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1147467-
Descrição: dc.descriptionThis study aimed at evaluating the effect of ractopamine (RAC) on metabolism, zootechnical performance, body composition, and behavior in Wistar rats submitted to acute and chronic restrain stress. The oral dose of 5 mg/kg of RAC was administered in periods of 0, 7, 14, 21, and 28 days. The elevated plus-maze test (EPMT) was used for behavioral assessment. Blood, carcass and viscera characteristics were evaluated. Insulin-dependent glucose transporters (GLUT-4) were semi-quantified by Western Blot in epididymal adipocytes. RAC periods associated with chronic stress increased the GLUT-4 protein expression in adipose tissue in a time-dependent manner (P=0.01), i.e., the longer the RAC addition period, the higher the GLUT-4 concentration in chronically stressed animals (0=1.42; 7=1.19; 14=2.03; 21=1.59; 28=2.35). The stress periods combined with RAC increased the time spent in the opened arms of the maze (Chronic stress: 0=10.6; 7=8.7; 14=5.9; 21=12.3; 28=4.0; Acute stress 0=3.1; 7= 4.7; 14=7.5; 21=0.0; 28=2.8) (P=0.04). Chronic (entries on the closed arms [ECA]=3.60) and acute (ECA=3.80) stress reduced locomotive activity in the maze (P=0.03). The results suggested that stress could negatively affect the possible benefits offered by the RAC, mainly impairing the adipose tissue metabolism and behavior in the animals.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Publicador: dc.publisherInstituto de Tecnologia do Paraná - Tecpar-
Direitos: dc.rightsacesso aberto-
Direitos: dc.rightshttp://creativecommons.org/licenses/by-nc/4.0/-
Direitos: dc.rightshttp://creativecommons.org/licenses/by-nc/4.0/-
???dc.source???: dc.sourceBrazilian Archives of Biology and Technology-
Palavras-chave: dc.subjectβ-adrenergic agonist-
Palavras-chave: dc.subjectRactopamine-
Palavras-chave: dc.subjectZootechnical performance-
Palavras-chave: dc.subjectMetabolism-
Palavras-chave: dc.subjectElevated Plus-Maze Tests-
Palavras-chave: dc.subjectAgonistas adrenérgicos beta-2-
Palavras-chave: dc.subjectRactopamina-
Palavras-chave: dc.subjectRato - Estresse-
Palavras-chave: dc.subjectDesempenho zootécnico-
Palavras-chave: dc.subjectTeste de labirinto em cruz elevado-
Título: dc.titleMetabolic and behavioral effects of ractopamine at continuous low levels in rats under stress-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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