Antitumor effects of snake venom chemically modified Lys49 phospholipase A2-like BthTX-I and a synthetic peptide derived from its C-terminal region

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorGebrim, Luiz Carlos-
Autor(es): dc.creatorMarcussi, Silvana-
Autor(es): dc.creatorMenaldo, Danilo L.-
Autor(es): dc.creatorMenezes, Carla S. R.de-
Autor(es): dc.creatorNomizo, Auro-
Autor(es): dc.creatorHamaguchi, Amélia-
Autor(es): dc.creatorSilveira-Lacerda, Elisângela P.-
Autor(es): dc.creatorHomsi-Brandeburgo, Maria Inês-
Autor(es): dc.creatorSampaio, Suely V.-
Autor(es): dc.creatorSoares, Andreimar M.-
Autor(es): dc.creatorRodrigues, Veridiana M.-
Data de aceite: dc.date.accessioned2026-02-09T11:47:04Z-
Data de disponibilização: dc.date.available2026-02-09T11:47:04Z-
Data de envio: dc.date.issued2020-05-18-
Data de envio: dc.date.issued2020-05-18-
Data de envio: dc.date.issued2009-08-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/40991-
Fonte completa do material: dc.identifierhttps://www.sciencedirect.com/science/article/pii/S1045105609000128-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1147390-
Descrição: dc.descriptionThe present work evaluates both in vitro and in vivo antitumor activity of BPB-modified BthTX-I and its cationic synthetic peptide derived from the 115–129 C-terminal region. BPB-BthTX-I presented cytotoxicity of 10–40% on different tumor cell lines, which were also susceptible to the lytic action of the synthetic peptide. Injection of the modified protein or the peptide in mice, 5 days after transplantation of S180 tumor cells, reduced 30 and 36% of the tumor size on day 14th and 76 and 79% on day 60th, respectively, when compared to the untreated control group. Thus, these antitumor properties might be of interest in the development of therapeutic strategies against cancer.-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceBiologicals-
Palavras-chave: dc.subjectBthTX-I-
Palavras-chave: dc.subjectBothrops jararacussu-
Palavras-chave: dc.subjectChemical modification-
Palavras-chave: dc.subjectBPB-
Palavras-chave: dc.subjectSynthetic peptide-
Palavras-chave: dc.subjectAntitumor activity-
Título: dc.titleAntitumor effects of snake venom chemically modified Lys49 phospholipase A2-like BthTX-I and a synthetic peptide derived from its C-terminal region-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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