Generation of a broadly useful model for COVID-19 pathogenesis, vaccination, and treatment

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Autor(es): dc.creatorSun, Jing-
Autor(es): dc.creatorZhuang, Zhen-
Autor(es): dc.creatorZheng, Jian-
Autor(es): dc.creatorLi, Kun-
Autor(es): dc.creatorWong, Roy Lok-Yin-
Autor(es): dc.creatorLiu, Donglan-
Autor(es): dc.creatorHuang, Jicheng-
Autor(es): dc.creatorHe, Jiangping-
Autor(es): dc.creatorZhu, Airu-
Autor(es): dc.creatorZhao, Jingxian-
Autor(es): dc.creatorLi, Xiaobo-
Autor(es): dc.creatorXi, Yin-
Autor(es): dc.creatorChen, Rongchang-
Autor(es): dc.creatorAlshukairi, Abeer N.-
Autor(es): dc.creatorChen, Zhao-
Autor(es): dc.creatorZhang, Zhaoyong-
Autor(es): dc.creatorChen, Chunke-
Autor(es): dc.creatorHuang, Xiaofang-
Autor(es): dc.creatorLi, Fang-
Autor(es): dc.creatorLai, Xiaomin-
Autor(es): dc.creatorChen, Dingbin-
Autor(es): dc.creatorWen, Liyan-
Autor(es): dc.creatorZhuo, Jianfen-
Autor(es): dc.creatorZhang, Yanjun-
Autor(es): dc.creatorWang, Yanqun-
Autor(es): dc.creatorHuang, Shuxiang-
Autor(es): dc.creatorDai, Jun-
Autor(es): dc.creatorShi, Yongxia-
Autor(es): dc.creatorZheng, Kui-
Autor(es): dc.creatorLeidinger, Mariah R.-
Autor(es): dc.creatorChen, Jiekai-
Autor(es): dc.creatorLi, Yimin-
Autor(es): dc.creatorZhong, Nanshan-
Autor(es): dc.creatorMeyerholz, David K.-
Autor(es): dc.creatorMcCray, Paul B.-
Autor(es): dc.creatorPerlman, Stanley-
Autor(es): dc.creatorZhao, Jincun-
Data de aceite: dc.date.accessioned2026-02-09T11:46:27Z-
Data de disponibilização: dc.date.available2026-02-09T11:46:27Z-
Data de envio: dc.date.issued2020-06-26-
Data de envio: dc.date.issued2020-06-26-
Data de envio: dc.date.issued2019-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/41582-
Fonte completa do material: dc.identifierhttps://www.sciencedirect.com/science/article/pii/S0092867420307418-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1147164-
Descrição: dc.descriptionCOVID-19, caused by SARS-CoV-2, is a virulent pneumonia, with >4,000,000 confirmed cases worldwide and >290,000 deaths as of May 15, 2020. It is critical that vaccines and therapeutics be developed very rapidly. Mice, the ideal animal for assessing such interventions, are resistant to SARS-CoV-2. Here, we overcome this difficulty by exogenous delivery of human ACE2 with a replication-deficient adenovirus (Ad5-hACE2). Ad5-hACE2-sensitized mice developed pneumonia characterized by weight loss, severe pulmonary pathology, and high-titer virus replication in lungs. Type I interferon, T cells, and, most importantly, signal transducer and activator of transcription 1 (STAT1) are critical for virus clearance and disease resolution in these mice. Ad5-hACE2-transduced mice enabled rapid assessments of a vaccine candidate, of human convalescent plasma, and of two antiviral therapies (poly I:C and remdesivir). In summary, we describe a murine model of broad and immediate utility to investigate COVID-19 pathogenesis and to evaluate new therapies and vaccines.-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceCell-
Palavras-chave: dc.subjectCOVID-19-
Palavras-chave: dc.subjectSevere Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-
Palavras-chave: dc.subjectMouse model-
Palavras-chave: dc.subjectPathogenesis-
Palavras-chave: dc.subjectTherapeutics-
Palavras-chave: dc.subjectVaccine-
Título: dc.titleGeneration of a broadly useful model for COVID-19 pathogenesis, vaccination, and treatment-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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