Biochemical characterization of SARS-CoV-2 nucleocapsid protein

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorZeng, Weihong-
Autor(es): dc.creatorLiu, Guangfeng-
Autor(es): dc.creatorMa, Huan-
Autor(es): dc.creatorZhao, Dan-
Autor(es): dc.creatorYang, Yunru-
Autor(es): dc.creatorLiu, Muziying-
Autor(es): dc.creatorMohammed, Ahmed-
Autor(es): dc.creatorZhao, Changcheng-
Autor(es): dc.creatorYang, Yun-
Autor(es): dc.creatorXie, Jiajia-
Autor(es): dc.creatorDing, Chengchao-
Autor(es): dc.creatorMa, Xiaoling-
Autor(es): dc.creatorWeng, Jianping-
Autor(es): dc.creatorGao, Yong-
Autor(es): dc.creatorHe, Hongliang-
Autor(es): dc.creatorJin, Tengchuan-
Data de aceite: dc.date.accessioned2026-02-09T11:45:25Z-
Data de disponibilização: dc.date.available2026-02-09T11:45:25Z-
Data de envio: dc.date.issued2020-05-27-
Data de envio: dc.date.issued2020-05-27-
Data de envio: dc.date.issued2019-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/41248-
Fonte completa do material: dc.identifierhttp://www.sciencedirect.com/science/article/pii/S0006291X20308767-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1146777-
Descrição: dc.descriptionThe nucleocapsid (N) protein is an important antigen for coronavirus, which participate in RNA package and virus particle release. In this study, we expressed the N protein of SARS-CoV-2 and characterized its biochemical properties. Static light scattering, size exclusive chromatography, and small-angle X-ray scattering (SAXS) showed that the purified N protein is largely a dimer in solution. CD spectra showed that it has a high percentage of disordered region at room temperature while it was best structured at 55 °C, suggesting its structural dynamics. Fluorescence polarization assay showed it has non-specific nucleic acid binding capability, which raised a concern in using it as a diagnostic marker. Immunoblot assays confirmed the presence of IgA, IgM and IgG antibodies against N antigen in COVID-19 infection patients’ sera, proving the importance of this antigen in host immunity and diagnostics.-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceBiochemical and Biophysical Research Communications-
Palavras-chave: dc.subjectCOVID-19-
Palavras-chave: dc.subjectSevere Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-
Palavras-chave: dc.subjectNucleocapsid protein-
Palavras-chave: dc.subjectSmall-angle X-ray scattering (SAXS)-
Palavras-chave: dc.subjectAntigenicity-
Título: dc.titleBiochemical characterization of SARS-CoV-2 nucleocapsid protein-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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