Placental-derived stem cells: Culture, differentiation and challenges

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorOliveira, Maira S.-
Autor(es): dc.creatorBarreto-Filho, João B.-
Data de aceite: dc.date.accessioned2026-02-09T11:44:41Z-
Data de disponibilização: dc.date.available2026-02-09T11:44:41Z-
Data de envio: dc.date.issued2019-11-27-
Data de envio: dc.date.issued2023-06-27-
Data de envio: dc.date.issued2019-11-27-
Data de envio: dc.date.issued2023-06-27-
Data de envio: dc.date.issued2015-05-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br//handle/1/57544-
Fonte completa do material: dc.identifierhttps://www.wjgnet.com/1948-0210/full/v7/i4/769.htm-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1146504-
Descrição: dc.descriptionStem cell therapy is a promising approach to clinical healing in several diseases. A great variety of tissues (bone marrow, adipose tissue, and placenta) are potentially sources of stem cells. Placenta-derived stem cells (p-SCs) are in between embryonic and mesenchymal stem cells, sharing characteristics with both, such as non-carcinogenic status and property to differentiate in all embryonic germ layers. Moreover, their use is not ethically restricted as fetal membranes are considered medical waste after birth. In this context, the present review will be focused on the biological properties, culture and potential cell therapy uses of placental-derived stem cells. Immunophenotype characterization, mainly for surface marker expression, and basic principles of p-SC isolation and culture (mechanical separation or enzymatic digestion of the tissues, the most used culture media, cell plating conditions) will be presented. In addition, some preclinical studies that were performed in different medical areas will be cited, focusing on neurological, liver, pancreatic, heart, muscle, pulmonary, and bone diseases and also in tissue engineering field. Finally, some challenges for stem cell therapy applications will be highlighted. The understanding of the mechanisms involved in the p-SCs differentiation and the achievement of pure cell populations (after differentiation) are key points that must be clarified before bringing the preclinical studies, performed at the bench, to the medical practice.-
Idioma: dc.languageen-
Publicador: dc.publisherBaishideng Publishing Group-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceWorld Journal of Stem Cells-
Palavras-chave: dc.subjectFetal membrane-
Palavras-chave: dc.subjectEmbryonic stem cells-
Palavras-chave: dc.subjectMesenchymal stem cells-
Palavras-chave: dc.subjectCell therapy-
Palavras-chave: dc.subjectMembrana fetal-
Palavras-chave: dc.subjectCélulas-tronco embrionárias-
Palavras-chave: dc.subjectCélulas-tronco mesenquimais-
Palavras-chave: dc.subjectTerapia celular-
Título: dc.titlePlacental-derived stem cells: Culture, differentiation and challenges-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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