Chalcone analogues: Synthesis, activity against Meloidogyne incognita, and in silico interaction with cytochrome P450

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorSilva, Fabíola J.-
Autor(es): dc.creatorCampos, Vicente P.-
Autor(es): dc.creatorOliveira, Denilson F.-
Autor(es): dc.creatorGomes, Vanessa A.-
Autor(es): dc.creatorBarros, Aline F.-
Autor(es): dc.creatorDin, Zia Ud-
Autor(es): dc.creatorRodrigues‐Filho, Edson-
Data de aceite: dc.date.accessioned2026-02-09T11:44:30Z-
Data de disponibilização: dc.date.available2026-02-09T11:44:30Z-
Data de envio: dc.date.issued2020-03-27-
Data de envio: dc.date.issued2020-03-27-
Data de envio: dc.date.issued2019-04-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/39489-
Fonte completa do material: dc.identifierhttps://onlinelibrary.wiley.com/doi/abs/10.1111/jph.12787-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1146438-
Descrição: dc.descriptionTo contribute the development of new products to control plant‐parasitic nematodes, 12 chalcone analogues were synthesized and screened for activity against Meloidogyne incognita. Three caused mortality greater than negative controls in second‐stage juvenile M. incognita, with values varying from 19.9% to 100%. The most active chalcone analogue was (1E,4E)‐1,5‐di(4‐nitrophenyl)‐2‐butylpenta‐1,4‐dien‐3‐one (compound 6), which had an LC50 value of 41 µg/ml. Under the same conditions, the commercial nematicide Carbofuran® (2,2‐dimethyl‐2,3‐dihydro‐1‐benzofuran‐7‐yl methylcarbamate) presented an LC50 equal to 101 µg/ml. When this chalcone analogue was applied to tomato plants infested with M. incognita, reductions in the numbers of galls and eggs of 51% and 68% were observed, respectively. According to in silico studies, the enzyme target of compound 6 in M. incongita is cytochrome P450, which is important for the oxidation of several substances in the nematode. Therefore, compound 6 is potentially useful for the development of new products to control M. incongita.-
Idioma: dc.languageen-
Publicador: dc.publisherBlackwell Verlag GmbH-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceJournal of Phytopathology-
Palavras-chave: dc.subjectChalcones-
Palavras-chave: dc.subjectSolanum lycopersicum-
Palavras-chave: dc.subjectPlant‐parasitic nematodes - Control-
Palavras-chave: dc.subjectRoot‐knot nematodes-
Palavras-chave: dc.subjectSolanum lycopersicum-
Palavras-chave: dc.subjectNematóides parasitas de plantas - Controle-
Palavras-chave: dc.subjectNematóides das galhas-
Título: dc.titleChalcone analogues: Synthesis, activity against Meloidogyne incognita, and in silico interaction with cytochrome P450-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

Não existem arquivos associados a este item.