Melatonin administration attenuates acute stress by inducing sleep state in zebrafish (Danio rerio)

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorLunkes, Luciana Crepaldi-
Autor(es): dc.creatorPaiva, Isadora Marques-
Autor(es): dc.creatorEgger, Renata Catão-
Autor(es): dc.creatorBraga, Weslley Fernandes-
Autor(es): dc.creatorAlvarez-Leite, Jacqueline Isaura-
Autor(es): dc.creatorVianna, André Rodrigues da Cunha Barreto-
Autor(es): dc.creatorMurgas, Luis David Solis-
Data de aceite: dc.date.accessioned2026-02-09T11:44:27Z-
Data de disponibilização: dc.date.available2026-02-09T11:44:27Z-
Data de envio: dc.date.issued2022-01-19-
Data de envio: dc.date.issued2023-06-27-
Data de envio: dc.date.issued2022-01-19-
Data de envio: dc.date.issued2023-06-27-
Data de envio: dc.date.issued2021-08-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br//handle/1/57948-
Fonte completa do material: dc.identifierhttps://doi.org/10.1016/j.cbpc.2021.109044-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1146418-
Descrição: dc.descriptionMelatonin plays a fundamental homeostatic role in basic biological functions, and an anti-stress role has been also proposed for this hormone. This study aimed to evaluate hormonal, enzymatic and behavioral parameters of zebrafish that received administration of melatonin and were submitted to acute stress. A total of 120 wild-type zebrafish were divided into five groups: naïve control (N), negative control group (Stress/C), positive control treated with diazepam (Stress/Diaz), treatment with melatonin at dose 1 (Stress/Melt. 1) and treatment with melatonin at dose 2 (Stress/Melt. 2). The exposure to treatments (diazepam or melatonin) was performed prior to the acute stress protocol, based on a chase by a fishing net during 5 min followed by exposure to the air for 1 min. The body cortisol levels were assessed, as well as oxidative stress (thiobarbituric acid reactive substances, reactive species of oxygen and antioxidant activity), and fish behavior (open field test). Melatonin was able to modulate acute stress effects on zebrafish by inhibiting cortisol increasing levels, reducing locomotor parameters, inducing a sleep state, reducing lipid peroxidation and stimulating antioxidant enzymatic activity.-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceComparative Biochemistry and Physiology Part C: Toxicology & Pharmacology-
Palavras-chave: dc.subjectFish - Hormone-
Palavras-chave: dc.subjectOxidative stress-
Palavras-chave: dc.subjectFish - Behavior-
Palavras-chave: dc.subjectFish - Anxiety-
Palavras-chave: dc.subjectMelatonin-
Palavras-chave: dc.subjectPeixes - Hormônio-
Palavras-chave: dc.subjectEstresse oxidativo-
Palavras-chave: dc.subjectPeixes - Comportamento-
Palavras-chave: dc.subjectPeixes - Ansiedade-
Palavras-chave: dc.subjectMelatonina-
Título: dc.titleMelatonin administration attenuates acute stress by inducing sleep state in zebrafish (Danio rerio)-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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