Immune mechanisms for increased risk of severe COVID-19 in Down syndrome

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorEspinosa, Joaquin M.-
Data de aceite: dc.date.accessioned2026-02-09T11:42:34Z-
Data de disponibilização: dc.date.available2026-02-09T11:42:34Z-
Data de envio: dc.date.issued2020-05-06-
Data de envio: dc.date.issued2020-05-06-
Data de envio: dc.date.issued2020-05-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/40612-
Fonte completa do material: dc.identifierhttps://www.sciencedirect.com/science/article/pii/S2666379120300240-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1145707-
Descrição: dc.descriptionPeople with Down syndrome show signs of chronic immune dysregulation, including higher prevalence of autoimmune disorders, increased rates of hospitalization during respiratory viral infections, and higher mortality rates from pneumonia and sepsis. At the molecular and cellular levels, they show markers of chronic autoinflammation, including interferon hyperactivity, elevated levels of many inflammatory cytokines and chemokines, and changes in diverse immune cell types reminiscent of inflammatory conditions observed in the general population. However, the impact of this immune dysregulation in SARS-CoV-2 infection and COVID-19 remains unknown. This Perspective will outline why individuals with Down syndrome should be considered an at-risk population for severe COVID-19. Specifically, the immune dysregulation caused by trisomy 21 may result in an exacerbated cytokine release syndrome relative to that observed in the euploid population, thus justifying additional monitoring and specialized care for this vulnerable population.-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceCell Reports Medicine-
Palavras-chave: dc.subjectSevere Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-
Palavras-chave: dc.subjectCOVID-19-
Palavras-chave: dc.subjectDown syndrome-
Palavras-chave: dc.subjectImmune dysregulation-
Título: dc.titleImmune mechanisms for increased risk of severe COVID-19 in Down syndrome-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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