COVID-19 Coronavirus spike protein analysis for synthetic vaccines, a peptidomimetic antagonist, and therapeutic drugs, and analysis of a proposed achilles’ heel conserved region to minimize probability of escape mutations and drug resistance

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorRobson, B.-
Data de aceite: dc.date.accessioned2026-02-09T11:42:08Z-
Data de disponibilização: dc.date.available2026-02-09T11:42:08Z-
Data de envio: dc.date.issued2020-04-15-
Data de envio: dc.date.issued2020-04-15-
Data de envio: dc.date.issued2020-04-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/40074-
Fonte completa do material: dc.identifierhttps://www.sciencedirect.com/science/article/pii/S0010482520301281-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1145539-
Descrição: dc.descriptionThis paper continues a recent study of the spike protein sequence of the COVID-19 virus (SARS-CoV-2). It is also in part an introductory review to relevant computational techniques for tackling viral threats, using COVID-19 as an example. Q-UEL tools for facilitating access to knowledge and bioinformatics tools were again used for efficiency, but the focus in this paper is even more on the virus. Subsequence KRSFIEDLLFNKV of the S2′ spike glycoprotein proteolytic cleavage site continues to appear important. Here it is shown to be recognizable in the common cold coronaviruses, avian coronaviruses and possibly as traces in the nidoviruses of reptiles and fish. Its function or functions thus seem important to the coronaviruses. It might represent SARS-CoV-2 Achilles’ Heel, less likely to acquire resistance by mutation, as has happened in some early SARS vaccine studies discussed in the previous paper. Preliminary conformational analysis of the receptor (ACE2) binding site of the spike protein is carried suggesting that while it is somewhat conserved, it appears to be more variable than KRSFIEDLLFNKV. However compounds like emodin that inhibit SARS entry, apparently by binding ACE2, might also have functions at several different human protein binding studies. The enzyme 11β-hydroxysteroid dehydrogenase type 1 is again argued to be a convenient model pharmacophore perhaps representing an ensemble of targets, and it is noted that it occurs both in lung and alimentary tract. Perhaps it benefits the virus to block an inflammatory response by inhibiting the dehydrogenase, but a fairly complex web involves several possible targets.-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceComputers in Biology and Medicine-
Palavras-chave: dc.subjectCoronavirus-
Palavras-chave: dc.subject2019-nCoV-
Palavras-chave: dc.subjectSevere Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-
Palavras-chave: dc.subjectCOVID-19-
Palavras-chave: dc.subjectWuhan seafood market coronavirus-
Palavras-chave: dc.subjectBionformatics-
Palavras-chave: dc.subjectSynthetic vaccine-
Palavras-chave: dc.subjectPeptidomimetic-
Palavras-chave: dc.subjectRetroinverso-
Palavras-chave: dc.subjectQ-UEL language-
Título: dc.titleCOVID-19 Coronavirus spike protein analysis for synthetic vaccines, a peptidomimetic antagonist, and therapeutic drugs, and analysis of a proposed achilles’ heel conserved region to minimize probability of escape mutations and drug resistance-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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