Pirfenidone: a novel hypothetical treatment for COVID-19

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorSeifirad, Soroush-
Data de aceite: dc.date.accessioned2026-02-09T11:42:05Z-
Data de disponibilização: dc.date.available2026-02-09T11:42:05Z-
Data de envio: dc.date.issued2020-06-23-
Data de envio: dc.date.issued2020-06-23-
Data de envio: dc.date.issued2020-10-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/41545-
Fonte completa do material: dc.identifierhttp://www.sciencedirect.com/science/article/pii/S0306987720308380-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1145521-
Descrição: dc.descriptionCytokine storm, multiorgan failure, and particularly acute respiratory distress syndrome (ARDS) is the leading cause of mortality and morbidity in patients with COVID-19. A fulminant ARDS kills the majority of COVID-19 victims. Pirfenidone (5-methyl-1-phenyl-2-[1H]-pyridone), is a novel anti-fibrotic agent with trivial adverse effects. Pirfenidone is approved for the treatment of Idiopathic Pulmonary Fibrosis (IPF) for patients with mild to moderate disease. Pirfenidone could inhibit apoptosis, downregulate ACE receptors expression, decrease inflammation by several mechanisms and ameliorate oxidative stress and hence protect pneumocytes and other cells from COVID-19 invasion and cytokine storm simultaneously. Based on the pirfenidone mechanism of action and the known pathophysiology of COVID-19, I believe that pirfenidone has the potential for the treatment of COVID-19 patients.-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceMedical Hypotheses-
Palavras-chave: dc.subjectCOVID-19-
Palavras-chave: dc.subjectPirfenidone-
Palavras-chave: dc.subjectCytokine storm-
Palavras-chave: dc.subjectOxidative stress-
Palavras-chave: dc.subjectInflammation-
Palavras-chave: dc.subjectAngiotensin-converting enzyme-
Palavras-chave: dc.subjectAcute Respiratory Distress Syndrome (ARDS)-
Título: dc.titlePirfenidone: a novel hypothetical treatment for COVID-19-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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