Mitochondriotropic action and DNA protection: Interactions between phenolic acids and enzymes

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorAbreu, Tatiane Silva de-
Autor(es): dc.creatorBraga, Mariana Aparecida-
Autor(es): dc.creatorSimão, Anderson Assaid-
Autor(es): dc.creatorTrento, Marcus Vinicius Cardoso-
Autor(es): dc.creatorEleutério, Mateus Willian de Faria-
Autor(es): dc.creatorPereira, Luciana Lopes Silva-
Autor(es): dc.creatorCunha, Elaine Fontes Ferreira da-
Autor(es): dc.creatorMarcussi, Silvana-
Data de aceite: dc.date.accessioned2026-02-09T11:40:01Z-
Data de disponibilização: dc.date.available2026-02-09T11:40:01Z-
Data de envio: dc.date.issued2020-05-18-
Data de envio: dc.date.issued2020-05-18-
Data de envio: dc.date.issued2019-12-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/41022-
Fonte completa do material: dc.identifierhttps://onlinelibrary.wiley.com/doi/full/10.1002/jbt.22417-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1144744-
Descrição: dc.descriptionThe protective action of caffeic (CA) and syringic (SA) acids on the genotoxicity exercised by snake venoms was investigated in this study. Molecular interactions between phenolic acids and the enzyme succinate dehydrogenase were also explored. In the electrophoresis assay, SA did not inhibit the genotoxicity induced by the venom. However, CA partially inhibited DNA degradation. In the comet assay, SA and CA exerted an inhibitory effect on the venom‐induced fragmentation. Succinate dehydrogenase presented, in computational analyzes, favorable energies to the molecular bond to both the malonic acid and the phenolic compounds evaluated. In the enzymatic activity assays, SA inhibited succinate dehydrogenase and interfered in the interaction of malonic acid. Meanwhile, CA potentiated the inhibition exerted by the malonic acid. The results suggest transient interactions between toxins present in venoms and phenolic acids, mainly by hydrogen interactions, which corroborate with the data from previous works.-
Idioma: dc.languageen-
Publicador: dc.publisherWiley-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceJournal of Biochemical and Molecular Toxicology-
Palavras-chave: dc.subjectComet assay-
Palavras-chave: dc.subjectEnzymatic inhibitor-
Palavras-chave: dc.subjectGenotoxicity-
Palavras-chave: dc.subjectPhenolic compounds-
Palavras-chave: dc.subjectSnake venom-
Palavras-chave: dc.subjectSuccinate dehydrogenase-
Título: dc.titleMitochondriotropic action and DNA protection: Interactions between phenolic acids and enzymes-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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