Development and validation of the MMCD score to predict kidney replacement therapy in COVID-19 patients

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorFigueiredo, Flávio de Azevedo-
Autor(es): dc.creatorRamos, Lucas Emanuel Ferreira-
Autor(es): dc.creatorSilva, Rafael Tavares-
Autor(es): dc.creatorPonce, Daniela-
Autor(es): dc.creatorCarvalho, Rafael Lima Rodrigues de-
Autor(es): dc.creatorSchwarzbold, Alexandre Vargas-
Autor(es): dc.creatorMaurílio, Amanda de Oliveira-
Autor(es): dc.creatorScotton, Ana Luiza Bahia Alves-
Autor(es): dc.creatorGarbini, Andresa Fontoura-
Autor(es): dc.creatorFarace, Bárbara Lopes-
Autor(es): dc.creatorGarcia, Bárbara Machado-
Autor(es): dc.creatorSilva, Carla Thais Cândida Alves da-
Autor(es): dc.creatorCimini, Christiane Corrêa Rodrigues-
Autor(es): dc.creatorCarvalho, Cíntia Alcantara de-
Autor(es): dc.creatorDias, Cristiane Dos Santos-
Autor(es): dc.creatorSilveira, Daniel Vitório-
Autor(es): dc.creatorManenti, Euler Roberto Fernandes-
Autor(es): dc.creatorCenci, Evelin Paola de Almeida-
Autor(es): dc.creatorAnschau, Fernando-
Autor(es): dc.creatorAranha, Fernando Graça-
Autor(es): dc.creatorAguiar, Filipe Carrilho de-
Autor(es): dc.creatorBartolazzi, Frederico-
Autor(es): dc.creatorVileta, Giovanna Grunewald-
Autor(es): dc.creatorNascimento, Guilherme Fagundes-
Autor(es): dc.creatorNoal, Helena Carolina-
Autor(es): dc.creatorDuani, Helena-
Autor(es): dc.creatorVianna, Heloisa Reniers-
Autor(es): dc.creatorGuimarães, Henrique Cerqueira-
Autor(es): dc.creatorAlvarenga, Joice Coutinho de-
Autor(es): dc.creatorChatkin, José Miguel-
Autor(es): dc.creatorMorais, Júlia Drumond Parreiras de-
Autor(es): dc.creatorMachado-Rugolo, Juliana-
Autor(es): dc.creatorRuschel, Karen Brasil-
Autor(es): dc.creatorMartins, Karina Paula Medeiros Prado-
Autor(es): dc.creatorMenezes, Luanna Silva Monteiro-
Autor(es): dc.creatorCouto, Luciana Siuves Ferreira-
Autor(es): dc.creatorCastro, Luís César de-
Autor(es): dc.creatorNasi, Luiz Antônio-
Autor(es): dc.creatorCabral, Máderson Alvares de Souza-
Autor(es): dc.creatorFloriani, Maiara Anschau-
Autor(es): dc.creatorSouza, Maíra Dias-
Autor(es): dc.creatorSilva, Maira Viana Rego Souza-
Autor(es): dc.creatorCarneiro, Marcelo-
Autor(es): dc.creatorGodoy, Mariana Frizzo de-
Autor(es): dc.creatorBicalho, Maria Aparecida Camargos-
Autor(es): dc.creatorLima, Maria Clara Pontello Barbosa-
Autor(es): dc.creatorAliberti, Márlon Juliano Romero-
Autor(es): dc.creatorNogueira, Matheus Carvalho Alves-
Autor(es): dc.creatorMartins, Matheus Fernandes Lopes-
Autor(es): dc.creatorGuimarães Júnior, Milton Henriques-
Autor(es): dc.creatorSampaio, Natália da Cunha Severino-
Autor(es): dc.creatorOliveira, Neimy Ramos de-
Autor(es): dc.creatorZiegelmann, Patricia Klarmann-
Autor(es): dc.creatorAndrade, Pedro Guido Soares-
Autor(es): dc.creatorAssaf, Pedro Ledic-
Autor(es): dc.creatorMartelli, Petrônio José de Lima-
Autor(es): dc.creatorPereira, Polianna Delfino-
Autor(es): dc.creatorMartins, Raphael Castro-
Autor(es): dc.creatorMenezes, Rochele Mosmann-
Autor(es): dc.creatorFrancisco, Saionara Cristina-
Autor(es): dc.creatorAraújo, Silvia Ferreira-
Autor(es): dc.creatorOliveira, Talita Fischer-
Autor(es): dc.creatorOliveira, Thainara Conceição de-
Autor(es): dc.creatorSales, Thaís Lorenna Souza-
Autor(es): dc.creatorSilva, Thiago Junqueira Avelino-
Autor(es): dc.creatorRamires, Yuri Carlotto-
Autor(es): dc.creatorPires, Magda Carvalho-
Autor(es): dc.creatorMarcolino, Milena Soriano-
Data de aceite: dc.date.accessioned2026-02-09T11:36:09Z-
Data de disponibilização: dc.date.available2026-02-09T11:36:09Z-
Data de envio: dc.date.issued2022-11-15-
Data de envio: dc.date.issued2022-11-15-
Data de envio: dc.date.issued2022-09-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/55506-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1143293-
Descrição: dc.descriptionBackground: Acute kidney injury (AKI) is frequently associated with COVID-19, and the need for kidney replacement therapy (KRT) is considered an indicator of disease severity. This study aimed to develop a prognostic score for pre‑ dicting the need for KRT in hospitalised COVID-19 patients, and to assess the incidence of AKI and KRT requirement. Methods: This study is part of a multicentre cohort, the Brazilian COVID-19 Registry. A total of 5212 adult COVID19 patients were included between March/2020 and September/2020. Variable selection was performed using generalised additive models (GAM), and least absolute shrinkage and selection operator (LASSO) regression was used for score derivation. Accuracy was assessed using the area under the receiver operating characteristic curve (AUC-ROC). Results: The median age of the model-derivation cohort was 59 (IQR 47–70) years, 54.5% were men, 34.3% required ICU admission, 20.9% evolved with AKI, 9.3% required KRT, and 15.1% died during hospitalisation. The temporal validation cohort had similar age, sex, ICU admission, AKI, required KRT distribution and in-hospital mortality. The geographic validation cohort had similar age and sex; however, this cohort had higher rates of ICU admission, AKI, need for KRT and in-hospital mortality. Four predictors of the need for KRT were identifed using GAM: need for mechanical ventilation, male sex, higher creatinine at hospital presentation and diabetes. The MMCD score had excellent discrimination in derivation (AUROC 0.929, 95% CI 0.918–0.939) and validation (tem‑ poral AUROC 0.927, 95% CI 0.911–0.941; geographic AUROC 0.819, 95% CI 0.792–0.845) cohorts and good overall performance (Brier score: 0.057, 0.056 and 0.122, respectively). The score is implemented in a freely available online risk calculator (https://www.mmcdscore.com/). Conclusions: The use of the MMCD score to predict the need for KRT may assist healthcare workers in identifying hospitalised COVID-19 patients who may require more intensive monitoring, and can be useful for resource allocation.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Publicador: dc.publisherSpringer Nature-
Direitos: dc.rightsacesso aberto-
Direitos: dc.rightshttp://creativecommons.org/licenses/by/4.0/-
Direitos: dc.rightshttp://creativecommons.org/licenses/by/4.0/-
???dc.source???: dc.sourceBMC Medicine-
Palavras-chave: dc.subjectAcute kidney injury-
Palavras-chave: dc.subjectCOVID-19-
Palavras-chave: dc.subjectKidney replacement therapy-
Palavras-chave: dc.subjectRisk factors-
Palavras-chave: dc.subjectRisk prediction-
Palavras-chave: dc.subjectScore-
Palavras-chave: dc.subjectLesão renal aguda-
Palavras-chave: dc.subjectTerapia renal substitutiva-
Palavras-chave: dc.subjectDoença renal - Fatores de risco-
Título: dc.titleDevelopment and validation of the MMCD score to predict kidney replacement therapy in COVID-19 patients-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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