Robust and specific secretory IgA against SARS-CoV-2 detected in human milk

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorFox, Alisa-
Autor(es): dc.creatorMarino, Jessica-
Autor(es): dc.creatorAmanat, Fatima-
Autor(es): dc.creatorKrammer, Florian-
Autor(es): dc.creatorHahn-Holbrook, Jennifer-
Autor(es): dc.creatorZolla-Pazner, Susan-
Autor(es): dc.creatorPowell, Rebecca L.-
Data de aceite: dc.date.accessioned2026-02-09T11:34:34Z-
Data de disponibilização: dc.date.available2026-02-09T11:34:34Z-
Data de envio: dc.date.issued2020-11-02-
Data de envio: dc.date.issued2020-11-02-
Data de envio: dc.date.issued2019-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/45343-
Fonte completa do material: dc.identifierhttps://www.sciencedirect.com/science/article/pii/S2589004220309329-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1142712-
Descrição: dc.descriptionThe SARS-CoV-2 immune response in human milk has not yet been examined, though protecting infants and young children from COVID-19 is critical for limiting community transmission, and preventing serious illness and death. Here, milk samples from 8 COVID-19-recovered and 7 COVID-19-suspected donors were tested for antibody (Ab) binding to the SARS-CoV-2 Spike protein. All samples exhibited significant specific IgA reactivity to the full Spike, while 80% exhibited significant IgA and secretory (s)Ab binding to the receptor binding domain (RBD). Additionally, 67% of samples exhibited IgG and/or IgM binding to RBD. IgA and sAb titers were highly correlated, indicating most IgA to be sIgA. Overall, these data indicate that a robust sIgA-dominant SARS-CoV-2 Ab response in human milk after infection should be expected in a significant majority of individuals. Further research is highly warranted to determine Ab functionality, and the potential for exploiting extracted milk sIgA for therapeutic use.-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceiScience-
Palavras-chave: dc.subjectCOVID-19-
Palavras-chave: dc.subjectSevere Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-
Palavras-chave: dc.subjectImmunoglobulin A (IgA)-
Palavras-chave: dc.subjectHuman milk-
Título: dc.titleRobust and specific secretory IgA against SARS-CoV-2 detected in human milk-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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