Assessment of the mutagenic, recombinogenic and carcinogenic potential of fipronil insecticide in somatic cells of Drosophila melanogaster

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorMorais, Cássio Resende de-
Autor(es): dc.creatorBonetti, Ana Maria-
Autor(es): dc.creatorCarvalho, Stephan Malfitano-
Autor(es): dc.creatorRezende, Alexandre Azenha Alves de-
Autor(es): dc.creatorAraujo, Galber Rodrigues-
Autor(es): dc.creatorSpanó, Mário Antônio-
Data de aceite: dc.date.accessioned2026-02-09T11:33:35Z-
Data de disponibilização: dc.date.available2026-02-09T11:33:35Z-
Data de envio: dc.date.issued2022-11-21-
Data de envio: dc.date.issued2022-11-21-
Data de envio: dc.date.issued2016-12-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/55558-
Fonte completa do material: dc.identifierhttps://www.sciencedirect.com/science/article/pii/S0045653516312127?via%3Dihub#!-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1142360-
Descrição: dc.descriptionFipronil (FP) is an insecticide that belongs to the phenylpyrazole chemical family and is used to control pests by blocking GABA receptor at the entrance channel of the chlorine neurons. The aim of this study was to evaluate the mutagenic, recombinogenic and carcinogenic potential of FP. The mutagenic and recombinogenic effects were evaluated using the somatic mutation and recombination test (SMART) on wing cells of Drosophila melanogaster. Third instar larvae from standard (ST) and high bioactivation (HB) crosses were treated with different concentrations of FP (0.3, 0.7, 1.5 or 3.0 × 10−5 mM). The results showed mutagenic effects at all concentrations tested in the HB cross; and all concentrations tested in the ST cross, except at concentration of 0.7 × 10−5 mM. The carcinogenic effect of FP was assayed through the test for detection of epithelial tumor (warts) in D. melanogaster. Third instar larvae from wts/TM3 virgin females mated to mwh/mwh males were treated with different concentrations of FP (0.3, 0.7, 1.5 or 3.0 × 10−5 mM). All these concentrations induced a statistically significant increase in tumor frequency. In conclusion, FP proved to be mutagenic, recombinogenic and carcinogenic in somatic cells of D. melanogaster.-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceChemosphere-
Palavras-chave: dc.subjectEpithelial tumor-
Palavras-chave: dc.subjectCarcinogenicity-
Palavras-chave: dc.subjectMutagenicity-
Palavras-chave: dc.subjectSomatic mutation and recombination test-
Palavras-chave: dc.subjectWarts-
Palavras-chave: dc.subjectTumor epitelial-
Palavras-chave: dc.subjectCarcinogenicidade-
Palavras-chave: dc.subjectMutagenicidade-
Palavras-chave: dc.subjectTeste de mutação somática e recombinação-
Título: dc.titleAssessment of the mutagenic, recombinogenic and carcinogenic potential of fipronil insecticide in somatic cells of Drosophila melanogaster-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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