Continuous tracking of COVID-19 patients' immune status

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Autor(es): dc.creatorGuan, Jingjing-
Autor(es): dc.creatorWei, Xin-
Autor(es): dc.creatorQin, Shuang-
Autor(es): dc.creatorLiu, Xiaoyuan-
Autor(es): dc.creatorJiang, Yujie-
Autor(es): dc.creatorChen, Yingxiao-
Autor(es): dc.creatorChen, Yanfan-
Autor(es): dc.creatorLu, Hong-
Autor(es): dc.creatorQian, Jingjing-
Autor(es): dc.creatorWang, Zhongyong-
Autor(es): dc.creatorLin, Xiangyang-
Data de aceite: dc.date.accessioned2026-02-09T11:28:06Z-
Data de disponibilização: dc.date.available2026-02-09T11:28:06Z-
Data de envio: dc.date.issued2020-10-25-
Data de envio: dc.date.issued2020-10-25-
Data de envio: dc.date.issued2020-11-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/43569-
Fonte completa do material: dc.identifierhttps://www.sciencedirect.com/science/article/pii/S1567576920323535-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1141414-
Descrição: dc.descriptionBackground COVID-19 is threating human health worldwide. We aim to investigate the dynamic changes of immune status in COVID-19 patients with clinical evolution. Methods Sixty-one COVID-19 patients (42 mild cases and 19 severe cases, 51 cases without secondary infection as non-infection group and 10 cases with secondary bacterial/fungal infection as infection group) and 52 healthy controls (HCs) were enrolled from our hospital. Leucocyte classification, lymphocyte subsets and cytokines were detected by full-automatic blood cell analyzer and flow cytometer, respectively. Results Upon admission, eosinophils and lymphocyte subsets decreased significantly, while neutrophils, monocytes, basophils, IL-2, IL-6, IL-10 and IFN-γ increased significantly in COVID-19 patients compared to HCs. CD3+ T and DN (CD3+CD4−CD8−) cells appeared sustained decline, leucocytes, neutrophils and IL-10 showed sustained increase in severe group compared to mild group. Compared with the non-infection group, we observed a depletion of eosinophils, CD3+ T and CD4+ T cells, but leucocytes, neutrophils, IL-6 and IL-10 on the contrary in the infection group. Besides, in severe group of COVID-19 patients, DN cells were negatively correlated with IL-10, and DP (CD3+CD4+CD8+) cells were negatively correlated with IL-6. Lymphocytes, eosinophils, CD3+ T cells, CD4+ T cells, IL-6 and IL-10 all had great diagnostic efficacy (AUC, 0.905-0.975) for COVID-19. The laboratory indicators of COVID-19 patients with improved condition also showed a recovery trend with time. Conclusions The immune status of COVID-19 patients is different in each stage, and dynamic monitoring of related indicators can help predict the disease and may avoid cytokine storms.-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceInternational Immunopharmacology-
Palavras-chave: dc.subjectCOVID-19-
Palavras-chave: dc.subjectImmune monitoring-
Palavras-chave: dc.subjectLymphocyte subsets-
Palavras-chave: dc.subjectCytokines-
Título: dc.titleContinuous tracking of COVID-19 patients' immune status-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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