Methyl esters of (E)-cinnamic acid: activity against the plant-parasitic nematode meloidogyne incognita and in silico interaction with histone deacetylase

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorVanegas, Javier A. G.-
Autor(es): dc.creatorPacule, Horácio B.-
Autor(es): dc.creatorCapitão, Rebeca M.-
Autor(es): dc.creatorCorreia, Carlos R. D.-
Autor(es): dc.creatorTerra, Willian C.-
Autor(es): dc.creatorCampos, Vicente P.-
Autor(es): dc.creatorOliveira, Denilson F.-
Data de aceite: dc.date.accessioned2026-02-09T11:26:51Z-
Data de disponibilização: dc.date.available2026-02-09T11:26:51Z-
Data de envio: dc.date.issued2022-06-24-
Data de envio: dc.date.issued2022-06-24-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/50344-
Fonte completa do material: dc.identifierhttps://doi.org/10.1021/acs.jafc.1c08142-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1140979-
Descrição: dc.description(E)-Cinnamaldehyde is very active against Meloidogyne incognita but has low persistence in soil. To circumvent this problem, esters of cinnamic acid were evaluated as a substitute for (E)-cinnamaldehyde. The best results under assays with M. incognita second-stage juveniles (J2) were obtained for the methyl esters of (E)-p-fluoro- (13), (E)-p-chloro- (14), and (E)-p-bromocinnamic acid (15), which showed lethal concentrations to 50% (LC50) J2 of 168, 95, and 216 μg/mL, respectively. Under the same conditions, the LC50 values for the nematicides carbofuran and fluensulfone were 160 and 34 μg/mL, respectively. Substances 13–15 were also active against nematode eggs, which account for most of the M. incognita population in the field. According to an in silico study, substances 13–15 can act against the nematode through inhibition of histone deacetylase. Therefore, esters 13–15 and histone deacetylase are potentially useful for the rational design of new nematicides for the control of M. incognita.-
Idioma: dc.languageen-
Publicador: dc.publisherAmerican Chemical Society-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceJournal of Agricultural and Food Chemistry-
Palavras-chave: dc.subjectMeloidogyne incognita-
Palavras-chave: dc.subjectHistone deacetylase-
Palavras-chave: dc.subjectHistone deacetylase-
Palavras-chave: dc.subject(E)-cinnamic acid-
Título: dc.titleMethyl esters of (E)-cinnamic acid: activity against the plant-parasitic nematode meloidogyne incognita and in silico interaction with histone deacetylase-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

Não existem arquivos associados a este item.