Acute treatment with Mangifera indica L. leaf extract attenuates liver inflammation in rats fed a cafeteria diet

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorToledo, Renata Celi Lopes-
Autor(es): dc.creatorBrito, Larissa Froede-
Autor(es): dc.creatorCaetano, Mônica Maria Magalhães-
Autor(es): dc.creatorNakajima, Vânia Mayumi-
Autor(es): dc.creatorSilva, Bárbara Pereira da-
Autor(es): dc.creatorSoares, Filippe Elias de Freitas-
Autor(es): dc.creatorMartino, Hércia Stampini Duarte-
Autor(es): dc.creatorQueiroz, José Humberto de-
Data de aceite: dc.date.accessioned2026-02-09T11:26:14Z-
Data de disponibilização: dc.date.available2026-02-09T11:26:14Z-
Data de envio: dc.date.issued2020-04-16-
Data de envio: dc.date.issued2020-04-16-
Data de envio: dc.date.issued2019-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/40110-
Fonte completa do material: dc.identifierhttps://pubs.rsc.org/en/content/articlelanding/2019/fo/c9fo00651f#!divAbstract-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1140778-
Descrição: dc.descriptionThis study investigates the acute anti-inflammatory activity of Mangifera indica L. leaf extract and mangiferin in the liver of rats fed a cafeteria diet. This study was a randomized longitudinal experimental study. The animals were divided into three groups – Control: cafeteria diet (CD); Extract: CD + leaf extract (250 mg kg−1); and Mangiferin: CD + mangiferin (40 mg kg−1). Body weight and food intake were measured every week. On day eight, mRNA and protein expression of inflammatory markers were evaluated in the liver. Also, liver weight, SOD activity and malondialdehyde concentration were measured. Treatment for only eight days with mango leaf extract and mangiferin increased SOD activity. Mangiferin intake increased the mRNA expression of PPAR-α and HSP72. The leaf extract treatment enhanced PPAR-α mRNA expression. Mangiferin and leaf extract consumption caused a lower concentration of NFκB (p65) in nuclear extracts, and greater IL-10 mRNA and protein levels. This study highlights the potential of acute treatment with mango leaf extract and mangiferin to prevent liver inflammation caused by fat-rich diets. These results indicate a new use for a product that has low cost, is found in great amounts, and is not routinely used.-
Idioma: dc.languageen-
Publicador: dc.publisherRoyal Society of Chemistry-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceFood and Function-
Título: dc.titleAcute treatment with Mangifera indica L. leaf extract attenuates liver inflammation in rats fed a cafeteria diet-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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