Cross-reactivity of anti-human cytokine monoclonal antibodies used as a tool to identify novel immunological biomarkers in domestic ruminants

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorDorneles, E. M. S.-
Autor(es): dc.creatorAraújo, M. S. S.-
Autor(es): dc.creatorTeixeira-Carvalho, A.-
Autor(es): dc.creatorLage, A. P.-
Data de aceite: dc.date.accessioned2026-02-09T11:25:21Z-
Data de disponibilização: dc.date.available2026-02-09T11:25:21Z-
Data de envio: dc.date.issued2018-02-23-
Data de envio: dc.date.issued2023-06-27-
Data de envio: dc.date.issued2018-02-23-
Data de envio: dc.date.issued2023-06-27-
Data de envio: dc.date.issued2015-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br//handle/1/57252-
Fonte completa do material: dc.identifierhttps://www.geneticsmr.com/articles/crossreactivity-of-antihuman-cytokine-monoclonal-antibodies-used-as-a-tool-to-identify-novel-immunological-biomarkers-in.pdf-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1140471-
Descrição: dc.descriptionEleven commercially available PE-labeled anti-human (IL-1-α, IL-6, IL-8, TNF-α, IL-17A, IL-5, IL-10, IL-12 and IL-13) and anti-mouse (IL-10, TNF-α) cytokine monoclonal antibodies (mAbs) were tested for cross-reactivity with cattle, goat, and sheep cytokines. Cross-reactivity was assessed by comparative analysis with the standard reactivity of the target species. Our data demonstrated that anti-human IL-1-α, IL-6, IL-8, IL-17A and IL-10 mAbs cross-react with all ruminant species tested. Anti-human IL-5 mAb showed a strong cross-reactivity with cattle and goat IL-5, while anti-human TNF-α mAb showed a selective cross-reactivity with goat TNF-α. No cross-reactivity with the ruminant cytokines was observed for anti-human IL-12 and IL-13 mAbs or for the two anti-mouse cytokine mAbs tested. The present study demonstrated the cross-reactivity of various anti-human cytokine mAbs with cattle, sheep, and goat cytokines, increasing the range of immunological biomarkers for studies in veterinary medicine.-
Idioma: dc.languageen-
Publicador: dc.publisherFundação de Pesquisas Científicas de Ribeirão Preto-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceGenetics and Molecular Research-
Palavras-chave: dc.subjectCytokines-
Palavras-chave: dc.subjectImmunological biomarkers-
Palavras-chave: dc.subjectCross-reactivity-
Palavras-chave: dc.subjectCitocinas-
Palavras-chave: dc.subjectBiomarcadores imunológicos-
Palavras-chave: dc.subjectReatividade cruzada-
Título: dc.titleCross-reactivity of anti-human cytokine monoclonal antibodies used as a tool to identify novel immunological biomarkers in domestic ruminants-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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