Inhibition of α-Glycosidase by Lippia dulcis Trevir. (Verbenaceae) preparations, quantification of verbascoside, and study of its molecular docking

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorRuas, Natalia Ritter-
Autor(es): dc.creatorPereira, Aline Carvalho-
Autor(es): dc.creatorPereira, Luciana Lopes Silva-
Autor(es): dc.creatorGermano, Carolina Mesquita-
Autor(es): dc.creatorCunha, Elaine Fontes Ferreira da-
Autor(es): dc.creatorCarvalho, Alexandre Alves de-
Autor(es): dc.creatorLameira, Osmar Alves-
Autor(es): dc.creatorPinto, José Eduardo Brasil Pereira-
Autor(es): dc.creatorBertolucci, Suzan Kelly Vilela-
Data de aceite: dc.date.accessioned2026-02-09T11:25:17Z-
Data de disponibilização: dc.date.available2026-02-09T11:25:17Z-
Data de envio: dc.date.issued2023-04-24-
Data de envio: dc.date.issued2023-04-24-
Data de envio: dc.date.issued2023-01-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/56695-
Fonte completa do material: dc.identifierhttps://onlinelibrary.wiley.com/doi/10.1002/cbdv.202200760-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1140444-
Descrição: dc.descriptionThis studyaimedto quantifyverbascoside(VEB),performmoleculardockingstudiesof VEB with theα-glucosidase(GL) ofBacillusstearothermophilus,and evaluatethe inhibitionof the enzymebyL. dulcispreparations.The substrateconcentrationand presenceof reducedglutathionewere evaluatedfor their effecton thein vitroinhibitionof the GL enzyme.Assayswere also performedin the presenceand absenceofsimulatedgastricfluid. The antidiabeticfractions2 and 3 were the most inhibitedGL, but their activityweresignificantlydecreasedin the presenceof gastricfluid. Chromatographicanalysesconfirmedthe predominantpresenceof VEB in the samples.The sampleshad VEB concentrationsbetween49.9 and 243.5 mg/g.Simulationof the moleculardockingof VEB were consistentwith its GL-inhibitoryactivity.It can concludethat the crudeethanolextractand fractionsshow inhibitoryactivityagainstthe GL enzyme.-
Idioma: dc.languageen-
Publicador: dc.publisherWiley-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceChemistry & Biodiversity-
Palavras-chave: dc.subjectMedicinal plant-
Palavras-chave: dc.subjectCapim doce-
Palavras-chave: dc.subjectHypoglycemic agent-
Palavras-chave: dc.subjectGlucosidase inhibitors-
Palavras-chave: dc.subjectPhenylethanoid glycoside-
Título: dc.titleInhibition of α-Glycosidase by Lippia dulcis Trevir. (Verbenaceae) preparations, quantification of verbascoside, and study of its molecular docking-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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