Factors associated with negative conversion of viral RNA in patients hospitalized with COVID-19

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorHu, Xiaowen-
Autor(es): dc.creatorXing, Yuhan-
Autor(es): dc.creatorJia, Jing-
Autor(es): dc.creatorNi, Wei-
Autor(es): dc.creatorLiang, Jiwei-
Autor(es): dc.creatorZhao, Dan-
Autor(es): dc.creatorSong, Xin-
Autor(es): dc.creatorGao, Ruqin-
Autor(es): dc.creatorJiang, Fachun-
Data de aceite: dc.date.accessioned2026-02-09T11:24:14Z-
Data de disponibilização: dc.date.available2026-02-09T11:24:14Z-
Data de envio: dc.date.issued2020-08-21-
Data de envio: dc.date.issued2020-08-21-
Data de envio: dc.date.issued2020-08-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/42517-
Fonte completa do material: dc.identifierhttps://www.sciencedirect.com/science/article/pii/S0048969720323299-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1140113-
Descrição: dc.descriptionFactors associated with negative conversion of SARS-CoV-2 RNA in hospitalized patients have not yet been systematically determined. We conducted a retrospective cohort study of COVID-19 patients in Qingdao, China. Both univariate and multivariate analysis were performed to identify independent factors for time to viral RNA negative conversion. Data on patients with re-detectable viral RNA after showing negative on RT-PCR test (intermittent negative status) were also analyzed. A total of 59 patients confirmed with COVID-19 were included in this study, with a median duration of 1 (interquartile range, IQR: 0–2) day from symptom onset to hospital admission. Median communicable period (from first day of positive nucleic acid test to first day of consecutive negative results) was 14 (IQR: 10–18) days, and 7 (IQR: 6–10) days for 10 patients with intermittent negative results. Age older than 45 years (hazard ratio, HR: 0.378; 95% confidence interval, CI: 0.205–0.698) and chest tightness (HR: 0.290; 95%CI: 0.091–0.919) were factors independently affecting negative conversion of SARS-CoV-2 RNA. Headache (odds ratio: 7.553; 95%CI: 1.011–28.253) was significantly associated with intermittent negative status, with a predicted probability of 60%. Older age and chest tightness were independently associated with delayed clearance of SARS-CoV-2 RNA in hospitalized patients. These predictors would provide a new perspective on early identification of patients with prolonged viral shedding and facilitate optimal isolation protocols and treatment strategies.-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceScience of The Total Environment-
Palavras-chave: dc.subjectCOVID-19-
Palavras-chave: dc.subjectSevere Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-
Palavras-chave: dc.subjectNegative conversion-
Palavras-chave: dc.subjectHazard ratio-
Título: dc.titleFactors associated with negative conversion of viral RNA in patients hospitalized with COVID-19-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

Não existem arquivos associados a este item.