Use of diffusion‐ordered NMR spectroscopy and HPLC-UV-SPE-NMR to identify undeclared synthetic drugs in medicines illegally sold as phytotherapies

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorSilva, Lorena M. A.-
Autor(es): dc.creatorA. Filho, Elenilson G.-
Autor(es): dc.creatorThomasi, Sérgio S.-
Autor(es): dc.creatorSilva, Bianca F.-
Autor(es): dc.creatorFerreira, Antonio G.-
Autor(es): dc.creatorVenâncio, Tiago-
Data de aceite: dc.date.accessioned2026-02-09T11:19:58Z-
Data de disponibilização: dc.date.available2026-02-09T11:19:58Z-
Data de envio: dc.date.issued2020-05-18-
Data de envio: dc.date.issued2020-05-18-
Data de envio: dc.date.issued2013-09-
Fonte completa do material: dc.identifierhttps://repositorio.ufla.br/handle/1/40984-
Fonte completa do material: dc.identifierhttps://onlinelibrary.wiley.com/doi/abs/10.1002/mrc.3984-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/1138635-
Descrição: dc.descriptionThe informal (and/or illegal) e‐commerce of pharmaceutical formulations causes problems that governmental health agencies find hard to control, one of which concerns formulas sold as natural products. The purpose of this work was to explore the advantages and limitations of DOSY and HPLC–UV–SPE–NMR. These techniques were used to identify the components of a formula illegally marketed in Brazil as an herbal medicine possessing anti‐inflammatory and analgesic properties. DOSY was able to detect the major components present at higher concentrations. Complete characterization was achieved using HPLC–UV–SPE–NMR, and 1D and 2D NMR analyses enabled the identification of known synthetic drugs. These were ranitidine and a mixture of orphenadrine citrate, piroxicam, and dexamethasone, which are co‐formulated in a remedy called Rheumazim that is used to relieve severe pain, but it is prohibited in Brazil because of a lack of sufficient pharmacokinetic and pharmacodynamic information.-
Idioma: dc.languageen-
Publicador: dc.publisherWiley-
Direitos: dc.rightsrestrictAccess-
???dc.source???: dc.sourceMagnetic Resonance in Chemistry-
Palavras-chave: dc.subjectDOSY-
Palavras-chave: dc.subjectHPLC-UV-SPE-NMR-
Palavras-chave: dc.subjectDrug adulteration-
Palavras-chave: dc.subjectUnknown formulas-
Palavras-chave: dc.subjectIllegal e‐commerce-
Palavras-chave: dc.subjectDiffusion-ordered spectroscopy (DOSY)-
Palavras-chave: dc.subjectHigh performance liquid chromatography coupled to on-line solid-phase extraction-nuclear magnetic resonance spectroscopy (HPLC-UV-SPE-NMR)-
Título: dc.titleUse of diffusion‐ordered NMR spectroscopy and HPLC-UV-SPE-NMR to identify undeclared synthetic drugs in medicines illegally sold as phytotherapies-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional da Universidade Federal de Lavras (RIUFLA)

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